Extracellular vesicles shed by glioma cells: pathogenic role and clinical value

Analysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades

(2014) Philip Alexandrovich Koshkin et al.   CLINICA CHIMICA ACTA

The role of regulatory T-cells in glioma immunology

(2014) Yinn Cher Ooi et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

(2014) Venugopal Thayanithy et al.   EXPERIMENTAL CELL RESEARCH

Emerging technologies in extracellular vesicle-based molecular diagnostics

(2014) Shidong Jia et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Regulation of exosome release by glycosphingolipids and flotillins

(2014) Santosh Phuyal et al.   FEBS Journal

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia

(2014) Fang-Fang Huang et al.   PLoS One

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration

(2014) W. Tris Arscott et al.   Translational Oncology

Exosomes from Murine-derived GL26 Cells Promote Glioblastoma Tumor Growth by Reducing Number and Function of CD8+T Cells

(2013) Zhi-Ming Liu et al.   Asian Pacific Journal of Cancer Prevention

Droplet Digital PCR Measurement of HER2 Copy Number Alteration in Formalin-Fixed Paraffin-Embedded Breast Carcinoma Tissue

(2013) P. Belgrader et al.   CLINICAL CHEMISTRY

Angiogenesis and Hypoxia in Glioblastoma: A Focus on Cancer Stem Cells

(2013) Maria Patrizia Mongiardi   CNS & Neurological Disorders-Drug Targets

Proteoglycans and their roles in brain cancer

(2013) Anna Wade et al.   FEBS Journal

The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

(2013) Hui K. Gan et al.   FEBS Journal

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor β-regulated MicroRNA-29a Promotes Angiogenesis through Targeting the Phosphatase and Tensin Homolog in Endothelium

(2013) Jun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin blocks transfer of extracellular vesicles between donor and recipient cells

(2013) Nadia A. Atai et al.   JOURNAL OF NEURO-ONCOLOGY

Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms

(2013) Edjah K. Nduom et al.   JOURNAL OF NEUROSURGERY

Screening for EGFR Amplifications with a Novel Method and Their Significance for the Outcome of Glioblastoma Patients

(2013) Michał Bieńkowski et al.   PLoS One

Latent Transforming Growth Factor β-Binding Protein 4 Is Downregulated in Esophageal Cancer via Promoter Methylation

(2013) Insa Bultmann et al.   PLoS One

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

(2013) Johnny C. Akers et al.   PLoS One

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

(2013) Cheryl CY Li et al.   RNA Biology

Glioma-Associated Stem Cells: A Novel Class of Tumor-Supporting Cells Able to Predict Prognosis of Human Low-Grade Gliomas

(2013) Evgenia Bourkoula et al.   STEM CELLS

Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth

(2013) Federica Verginelli et al.   Nature Communications

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

(2013) Walter W Chen et al.   Molecular Therapy-Nucleic Acids

Direct Quantification of MicroRNA at Low Picomolar Level in Sera of Glioma Patients Using a Competitive Hybridization Followed by Amplified Voltammetric Detection

(2012) Jianxiu Wang et al.   ANALYTICAL CHEMISTRY

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

(2012) Mikkel Noerholm et al.   BMC CANCER

Molecular pathogenesis of IDH mutations in gliomas

(2012) Koichi Ichimura   Brain Tumor Pathology

EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-κB activation

(2012) Helena Kiefel et al.   CARCINOGENESIS

L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor

(2012) Vishnu Mohanan et al.   CLINICAL & EXPERIMENTAL METASTASIS

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Contribution of microRNAs to radio- and chemoresistance of brain tumors and their therapeutic potential

(2012) Dimitry A. Chistiakov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential requirements of mammalian ESCRTs in multivesicular body formation, virus budding and cell division

(2012) Eiji Morita   FEBS Journal

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation

(2012) C. G. Duncan et al.   GENOME RESEARCH

Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas

(2012) Cuihua Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma

(2012) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

(2012) M. Lucrecia Alvarez et al.   KIDNEY INTERNATIONAL

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

(2012) N. M. Teplyuk et al.   NEURO-ONCOLOGY

Medulloblastoma Exosome Proteomics Yield Functional Roles for Extracellular Vesicles

(2012) Laura M. Epple et al.   PLoS One

Structural studies of large nucleoprotein particles, vaults

(2012) Hideaki TANAKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

PDGF and PDGF receptors in glioma

(2012) Inga Nazarenko et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

L1CAM

(2012) Helena Kiefel et al.   Cell Adhesion & Migration

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Blood platelets contain tumor-derived RNA biomarkers

(2011) R. J. A. Nilsson et al.   BLOOD

Microvesicles: Messengers and mediators of tumor progression

(2011) Khalid Al-Nedawi et al.   CELL CYCLE

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop

(2011) Lili Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

L1 stimulation of human glioma cell motility correlates with FAK activation

(2011) Muhua Yang et al.   JOURNAL OF NEURO-ONCOLOGY

Exosome-loaded dendritic cells elicit tumor-specific CD8+ cytotoxic T cells in patients with glioma

(2011) Ning Bu et al.   JOURNAL OF NEURO-ONCOLOGY

Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion

(2011) Lincoln A. Edwards et al.   JNCI-Journal of the National Cancer Institute

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

(2011) Katrin J. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Latent transforming growth factor binding protein 4 (LTBP4) is downregulated in mouse and human DCIS and mammary carcinomas

(2011) Celine Kretschmer et al.   CELLULAR ONCOLOGY

Apoptosis and the target genes of microRNA-21

(2011) Lindsey E. Becker Buscaglia et al.   Chinese Journal of Cancer

IGFBP2 promotes glioma tumor stem cell expansion and survival

(2010) David Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN Signaling pathways in glioblastoma

(2010) Dimpy Koul   CANCER BIOLOGY & THERAPY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes

(2010) Lei Nie et al.   CELL RESEARCH

MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells

(2010) Zhimin Li et al.   GYNECOLOGIC ONCOLOGY

Mesenchymal stem cells: A promising targeted-delivery vehicle in cancer gene therapy

(2010) Yu-Lan Hu et al.   JOURNAL OF CONTROLLED RELEASE

IL-10 and TGF-β2 are overexpressed in tumor spheres cultured from human gliomas

(2010) Bo Qiu et al.   MOLECULAR BIOLOGY REPORTS

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Antiglioma effects of a new, low molecular mass, inhibitor of fibroblast growth factor

(2010) Pedro Cuevas et al.   NEUROSCIENCE LETTERS

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma

(2009) T. Krejsgaard et al.   BLOOD

Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule

(2009) Muhua Yang et al.   Cancer Cell International

Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death

(2009) Miia Bovellan et al.   FEBS Journal

Analysis of interleukin (IL)-8 expression in human astrocytomas: Associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry

(2009) Vassilis Samaras et al.   HUMAN IMMUNOLOGY

Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness

(2009) Ahlame Saidi et al.   INTERNATIONAL JOURNAL OF CANCER

Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia

(2009) Arnab Pal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Cell-derived microparticles: a new challenge in neuroscience

(2009) Loïc Doeuvre et al.   JOURNAL OF NEUROCHEMISTRY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs

(2009) Helena Persson et al.   NATURE CELL BIOLOGY

Dendritic Cell Vaccines for Brain Tumors

(2009) Won Kim et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

(2008) Hua Zhu et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

(2008) Yang Chen et al.   CANCER LETTERS

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity

(2008) W. Berger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fibronectin and heparin binding domains of latent TGF-β binding protein (LTBP)-4 mediate matrix targeting and cell adhesion

(2008) A KANTOLA et al.   EXPERIMENTAL CELL RESEARCH

The RGD integrin binding site in human L1-CAM is important for nuclear signaling

(2008) D GAST et al.   EXPERIMENTAL CELL RESEARCH

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Functions and mechanisms of action of CCN matricellular proteins

(2008) Chih-Chiun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemoresistance in gliomas

(2008) Chen Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Membrane nanotubes: dynamic long-distance connections between animal cells

(2008) Daniel M. Davis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN signaling in brain: neuropathology and tumorigenesis

(2008) R Endersby et al.   ONCOGENE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Mechanisms for enveloped virus budding: Can some viruses do without an ESCRT?

(2007) Benjamin J. Chen et al.   VIROLOGY