Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular traps formation leading to a more efficient bacterial clearance in mice

(2012) V. I. Landoni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Arthroderma benhamiae Hydrophobin HypA Mediates Hydrophobicity and Influences Recognition by Human Immune Effector Cells

(2012) Christoph Heddergott et al.   EUKARYOTIC CELL

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Afa/Dr Diffusely Adhering Escherichia coli Strain C1845 Induces Neutrophil Extracellular Traps That Kill Bacteria and Damage Human Enterocyte-Like Cells

(2012) Viviana Marin-Esteban et al.   INFECTION AND IMMUNITY

α-Enolase of Streptococcus pneumoniae Induces Formation of Neutrophil Extracellular Traps

(2012) Yuka Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil superoxide production in the presence of cigarette smoke extract, nicotine and cotinine

(2012) John B. Matthews et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation

(2012) Willem Nesse et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

In vitro effects of Escherichia coli lipopolysaccharide on the function and gene expression of neutrophils isolated from the blood of dairy cows

(2012) X.S. Revelo et al.   JOURNAL OF DAIRY SCIENCE

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

(2012) C. Allen et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Removal of Biofilms from Tracheoesophageal Speech Valves Using a Novel Marine Microbial Deoxyribonuclease

(2012) Adam Shakir et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis

(2012) Amanda S Rohrbach et al.   ARTHRITIS RESEARCH & THERAPY

Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease

(2011) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Singlet oxygen is essential for neutrophil extracellular trap formation

(2011) Yoko Nishinaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Killing by neutrophil extracellular traps: fact or folklore?

(2011) R. Menegazzi et al.   BLOOD

Hypochlorous acid regulates neutrophil extracellular trap release in humans

(2011) L. J. Palmer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Effect of nicotine, cotinine and cigarette smoke extract on the neutrophil respiratory burst

(2011) John B. Matthews et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

How is the development of dental biofilms influenced by the host?

(2011) Philip D. Marsh et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate Immune Collectin Surfactant Protein D Simultaneously Binds Both Neutrophil Extracellular Traps and Carbohydrate Ligands and Promotes Bacterial Trapping

(2011) D. N. Douda et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena?

(2011) C. Galli et al.   JOURNAL OF PERIODONTAL RESEARCH

Extracellular deoxyribonuclease production by periodontal bacteria

(2011) L. J. Palmer et al.   JOURNAL OF PERIODONTAL RESEARCH

Extracellular DNA: The tip of root defenses?

(2011) Martha C. Hawes et al.   PLANT SCIENCE

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Autopathogenic correlation of periodontitis and rheumatoid arthritis

(2011) J. G. Routsias et al.   RHEUMATOLOGY

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Statins Enhance Formation of Phagocyte Extracellular Traps

(2010) Ohn A. Chow et al.   Cell Host & Microbe

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

NontypeableHaemophilus influenzaeInitiates Formation of Neutrophil Extracellular Traps

(2010) Richard A. Juneau et al.   INFECTION AND IMMUNITY

Mannheimia haemolytica and Its Leukotoxin Cause Neutrophil Extracellular Trap Formation by Bovine Neutrophils

(2010) N. A. Aulik et al.   INFECTION AND IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines

(2010) Irundika H. K. Dias et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation

(2010) Satyananda Patel et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The road to ruin: the formation of disease-associated oral biofilms

(2010) NS Jakubovics et al.   ORAL DISEASES

Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

(2010) Anna L. Cogen et al.   PLoS One

Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions

(2010) Deborah J. Springer et al.   PLoS One

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Fate in Gingival Crevicular Fluid

(2010) Ljubomir Vitkov et al.   ULTRASTRUCTURAL PATHOLOGY

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

(2009) C. C. Yost et al.   BLOOD

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Immune Complex–Mediated Neutrophil Recruitment and Tissue Injury

(2009) Tanya N. Mayadas et al.   CIRCULATION

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

(2009) A. B. Wardini et al.   JOURNAL OF GENERAL VIROLOGY

Streptococcus pneumoniaeForms Surface‐Attached Communities in the Middle Ear of Experimentally Infected Chinchillas

(2009) Sean D. Reid et al.   JOURNAL OF INFECTIOUS DISEASES

Activation of the Human Contact System on Neutrophil Extracellular Traps

(2009) Sonja Oehmcke et al.   Journal of Innate Immunity

DNase I Inhibits a Late Phase of Reactive Oxygen Species Production in Neutrophils

(2009) Daniela B. Munafo et al.   Journal of Innate Immunity

Survival of Bacterial Biofilms within Neutrophil Extracellular Traps Promotes Nontypeable Haemophilus influenzae Persistence in the Chinchilla Model for Otitis Media

(2009) Wenzhou Hong et al.   Journal of Innate Immunity

Mouse Neutrophil Extracellular Traps in Microbial Infections

(2009) David Ermert et al.   Journal of Innate Immunity

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

M1 Protein Allows Group A Streptococcal Survival in Phagocyte Extracellular Traps through Cathelicidin Inhibition

(2009) Xavier Lauth et al.   Journal of Innate Immunity

Diagnostic accuracy of neutrophil-derived circulating free DNA (cf-DNA/NETs) for septic arthritis

(2009) Tim Lögters et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Extracellular neutrophil traps in periodontitis

(2009) L. Vitkov et al.   JOURNAL OF PERIODONTAL RESEARCH

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Periodontitis in systemic rheumatic diseases

(2009) Paola de Pablo et al.   Nature Reviews Rheumatology

Extracellular DNA Is Required for Root Tip Resistance to Fungal Infection

(2009) F. Wen et al.   PLANT PHYSIOLOGY

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular trap formation as innate immune reactions against the apicomplexan parasite Eimeria bovis

(2009) Jan Hillern Behrendt et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

 -Hydroxybutyrate Abrogates Formation of Bovine Neutrophil Extracellular Traps and Bactericidal Activity against Mammary Pathogenic Escherichia coli

(2008) N. Grinberg et al.   INFECTION AND IMMUNITY

Controlling the Resolution of Acute Inflammation: A New Genus of Dual Anti-Inflammatory and Proresolving Mediators

(2008) Charles N. Serhan   JOURNAL OF PERIODONTOLOGY

The Management of Inflammation in Periodontal Disease

(2008) Thomas E. Van Dyke   JOURNAL OF PERIODONTOLOGY

The innate immune system in SLE: type I interferons and dendritic cells

(2008) L Rönnblom et al.   LUPUS

Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age

(2008) Virginia S Baker et al.   MALARIA JOURNAL

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

PAI-1 inhibits neutrophil efferocytosis

(2008) Y.-J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

(2008) Victoria Ramos-Kichik et al.   TUBERCULOSIS

Visualization of neutrophil extracellular traps in TEM

(2007) Wolf Dietrich Krautgartner et al.   MICRON