Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1

HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE

(2020) Hongki Song et al.   eLife

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

(2019) Shen Wang et al.   Nature Communications

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and aSNAP

(2019) Eric A Prinslow et al.   eLife

Membrane bridging by Munc13-1 is crucial for neurotransmitter release

(2019) Bradley Quade et al.   eLife

Tethering guides fusion-competenttrans-SNARE assembly

(2019) Hongki Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

(2019) Karolina P. Stepien et al.   Nature Communications

Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex

(2019) Tong Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Fast Neurotransmitter Release

(2018) Axel T. Brunger et al.   Annual Review of Biophysics

Mechanism of neurotransmitter release coming into focus

(2018) Josep Rizo   PROTEIN SCIENCE

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

(2018) Junyi Jiao et al.   eLife

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 inCaenorhabditis elegans

(2017) Seungmee Park et al.   JOURNAL OF NEUROSCIENCE

A cascade of multiple proteins and lipids catalyzes membrane fusion

(2017) William Wickner et al.   MOLECULAR BIOLOGY OF THE CELL

The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis

(2017) Qiangjun Zhou et al.   NATURE

Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion

(2017) Xiaoxia Liu et al.   Nature Protocols

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

(2017) Ewa Sitarska et al.   eLife

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

(2017) Junjie Xu et al.   eLife

Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency

(2016) Jaewook Kim et al.   BIOCHEMISTRY

Functional synergy between the Munc13 C-terminal C1 and C2 domains

(2016) Xiaoxia Liu et al.   eLife

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

(2014) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Enlightening molecular mechanisms through study of protein interactions

(2012) Josep Rizo et al.   Journal of Molecular Cell Biology

Short-Term Presynaptic Plasticity

(2012) W. G. Regehr   Cold Spring Harbor Perspectives in Biology

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation

(2011) K. D. Brewer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle

(2010) Yi Xu et al.   BIOCHEMISTRY

Methyl groups as probes of supra-molecular structure, dynamics and function

(2009) Amy M. Ruschak et al.   JOURNAL OF BIOMOLECULAR NMR

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

NMR analysis of the closed conformation of syntaxin-1

(2008) Xiaocheng Chen et al.   JOURNAL OF BIOMOLECULAR NMR

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE