Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion

The Synaptic Vesicle Release Machinery

(2015) Josep Rizo et al.   Annual Review of Biophysics

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sec17 can trigger fusion oftrans-SNARE paired membranes without Sec18

(2015) Michael Zick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex

(2013) Junjie Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Fusion pore formation and expansion induced by Ca2+and synaptotagmin 1

(2013) Ying Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

(2011) Wei Li et al.   STRUCTURE

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

(2010) H. K. Lee et al.   SCIENCE

Lipid Mixing and Content Release in Single-Vesicle, SNARE-Driven Fusion Assay with 1–5 ms Resolution

(2009) Tingting Wang et al.   BIOPHYSICAL JOURNAL

Single Vesicle Millisecond Fusion Kinetics Reveals Number of SNARE Complexes Optimal for Fast SNARE-mediated Membrane Fusion

(2009) Marta K. Domanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotides

(2009) Y.-H. M. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

(2008) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density

(2008) Elena O. Gracheva et al.   NEUROSCIENCE LETTERS