Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and aSNAP

(2019) Eric A Prinslow et al.   eLife

Membrane bridging by Munc13-1 is crucial for neurotransmitter release

(2019) Bradley Quade et al.   eLife

Molecular Mechanisms of Fast Neurotransmitter Release

(2018) Axel T. Brunger et al.   Annual Review of Biophysics

Arrest oftrans-SNARE zippering uncovers loosely and tightly docked intermediates in membrane fusion

(2018) Halenur Yavuz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of neurotransmitter release coming into focus

(2018) Josep Rizo   PROTEIN SCIENCE

NSF-mediated disassembly of on and off-pathway SNARE complexes and inhibition by complexin

(2018) Ucheor B Choi et al.   eLife

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

(2018) Junyi Jiao et al.   eLife

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 inCaenorhabditis elegans

(2017) Seungmee Park et al.   JOURNAL OF NEUROSCIENCE

Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion

(2017) Xiaoxia Liu et al.   Nature Protocols

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

(2017) Enqi He et al.   Nature Communications

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

(2017) Matthew L Schwartz et al.   eLife

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

(2017) Ewa Sitarska et al.   eLife

Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

(2017) Hongki Song et al.   eLife

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

(2017) Junjie Xu et al.   eLife

α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle

(2016) Lu Ma et al.   Cell Reports

Functional synergy between the Munc13 C-terminal C1 and C2 domains

(2016) Xiaoxia Liu et al.   eLife

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sec17 can trigger fusion oftrans-SNARE paired membranes without Sec18

(2015) Michael Zick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-SNAP Interferes with the Zippering of the SNARE Protein Membrane Fusion Machinery

(2014) Yongsoo Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

(2014) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ

(2013) A. Pertsinidis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate

(2013) B. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Enlightening molecular mechanisms through study of protein interactions

(2012) Josep Rizo et al.   Journal of Molecular Cell Biology

Short-Term Presynaptic Plasticity

(2012) W. G. Regehr   Cold Spring Harbor Perspectives in Biology

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-SNAP Prevents Docking of the Acrosome during Sperm Exocytosis because It Sequesters Monomeric Syntaxin

(2011) Facundo Rodríguez et al.   PLoS One

Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation

(2011) K. D. Brewer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNARE Protein Recycling by αSNAP and βSNAP Supports Synaptic Vesicle Priming

(2010) Andrea Burgalossi et al.   NEURON

Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

(2010) H. K. Lee et al.   SCIENCE

A Conserved Membrane Attachment Site in α-SNAP FacilitatesN-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly

(2009) Ulrike Winter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capture and release of partially zipped trans-SNARE complexes on intact organelles

(2009) Matthew L. Schwartz et al.   JOURNAL OF CELL BIOLOGY

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

NMR analysis of the closed conformation of syntaxin-1

(2008) Xiaocheng Chen et al.   JOURNAL OF BIOMOLECULAR NMR

A Novel Site of Action for α-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion

(2007) Marcin Barszczewski et al.   MOLECULAR BIOLOGY OF THE CELL