Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

(2017) Iva A Tchasovnikarova et al.   NATURE GENETICS

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

(2017) Christopher T Gordon et al.   NATURE GENETICS

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

(2017) Natalie D Shaw et al.   NATURE GENETICS

MORC2mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs

(2016) Obaid M. Albulym et al.   ANNALS OF NEUROLOGY

The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain

(2016) K. Chen et al.   BIOCHEMICAL JOURNAL

Severe axonal Charcot-Marie-Tooth disease with proximal weakness caused byde novomutation in theMORC2gene

(2016) Petra Laššuthová et al.   BRAIN

MORC2 mutation causes severe spinal muscular atrophy-phenotype, cerebellar atrophy, and diaphragmatic paralysis

(2016) Gudrun Schottmann et al.   BRAIN

Clinico-genetics in Korean Charcot-Marie-Tooth disease type 2Z withMORC2mutations

(2016) Young Se Hyun et al.   BRAIN

MORC2mutations in a cohort of Chinese patients with Charcot–Marie–Tooth disease type 2

(2016) Xin Zhao et al.   BRAIN

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins

(2016) Yanli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

(2016) Sisi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase

(2016) Forest H. Andrews et al.   Cell Reports

Mutations in theMORC2gene cause axonal Charcot–Marie–Tooth disease

(2015) Teresa Sevilla et al.   BRAIN

Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome

(2015) Nicholas J. Brideau et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

(2015) Kelan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

Low-resolution refinement in the programREFMAC

(2015) G. N. Murshudov   ACTA CRYSTALLOGRAPHICA SECTION A

MORC1 represses transposable elements in the mouse male germline

(2014) William A. Pastor et al.   Nature Communications

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

Involvement of a GHKL ATPase in RNA-Directed DNA Methylation in Arabidopsis thaliana

(2012) Zdravko J. Lorković et al.   CURRENT BIOLOGY

Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice

(2012) Katherine V. Bricceno et al.   HUMAN MOLECULAR GENETICS

MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing

(2012) G. Moissiard et al.   SCIENCE

MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response

(2012) Da-Qiang Li et al.   Cell Reports

CaSeO4·0.625H2O – water channel occupation in a bassanite related structure

(2011) Susanne Fritz et al.   ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE

Prediction of Hydrodynamic and Other Solution Properties of Rigid Proteins from Atomic- and Residue-Level Models

(2011) A. Ortega et al.   BIOPHYSICAL JOURNAL

Two-step colocalization of MORC3 with PML nuclear bodies

(2010) Y. Mimura et al.   JOURNAL OF CELL SCIENCE

Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX

(2010) Yangguang Shao et al.   NUCLEIC ACIDS RESEARCH

The MORPHEUS protein crystallization screen

(2009) Fabrice Gorrec   JOURNAL OF APPLIED CRYSTALLOGRAPHY