Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

(2016) Xiaofeng Liu et al.   EMBO REPORTS

Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

(2015) Alexander M. Aliper et al.   Aging-US

Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly

(2015) Benjamin Vollmer et al.   DEVELOPMENTAL CELL

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

(2015) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome

(2014) Leslie B. Gordon et al.   CIRCULATION

Human NAT10 Is an ATP-dependent RNA Acetyltransferase Responsible forN4-Acetylcytidine Formation in 18 S Ribosomal RNA (rRNA)

(2014) Satoshi Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A pathway linking oxidative stress and the Ran GTPase system in progeria

(2014) Sutirtha Datta et al.   MOLECULAR BIOLOGY OF THE CELL

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

(2013) Chelsi J. Snow et al.   JOURNAL OF CELL BIOLOGY

Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

(2012) Baohua Liu et al.   Cell Metabolism

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9

(2011) J. B. Kelley et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

(2010) Sandra Krull et al.   EMBO JOURNAL

hALP, A Novel Transcriptional U Three Protein (t-UTP), Activates RNA Polymerase I Transcription by Binding and Acetylating the Upstream Binding Factor (UBF)

(2010) Ruirui Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition

(2010) Jackleen Marji et al.   PLoS One

Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome

(2010) Juan M. Vaquerizas et al.   PLoS Genetics

Transportin Regulates Major Mitotic Assembly Events: From Spindle to Nuclear Pore Assembly

(2009) Corine K. Lau et al.   MOLECULAR BIOLOGY OF THE CELL

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE