The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

(2019) Paolo Gelosa et al.   PHARMACOLOGICAL RESEARCH

The Role of Inflammation in Depression and Fatigue

(2019) Chieh-Hsin Lee et al.   Frontiers in Immunology

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

(2019) Marie-Laure Arotcarena et al.   Cells

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

CysLTR1 Blockage Ameliorates Liver Injury Caused by Aluminum-Overload via PI3K/AKT/mTOR-Mediated Autophagy Activation in Vivo and in Vitro

(2018) Congli Hu et al.   MOLECULAR PHARMACEUTICS

Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

(2018) Jose-Alberto Palma et al.   MOVEMENT DISORDERS

The leukotriene signaling pathway: a druggable target in Alzheimer’s disease

(2018) Johanna Michael et al.   DRUG DISCOVERY TODAY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson’s disease

(2017) Hannah Jang et al.   NEUROREPORT

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

(2017) Shuchi Mittal et al.   SCIENCE

Prescription database analyses indicates that the asthma medicine montelukast might protect against dementia: a hypothesis to be verified

(2017) Bjørn Grinde et al.   Immunity & Ageing

Microglia in dementia with Lewy bodies

(2016) Wolfgang J. Streit et al.   BRAIN BEHAVIOR AND IMMUNITY

Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies

(2016) John H. T. Power et al.   BRAIN PATHOLOGY

Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice

(2016) Chun Teng Zhang et al.   NEUROTOXICOLOGY

Montelukast, current indications and prospective future applications

(2016) Naim Kittana et al.   Expert Review of Respiratory Medicine

The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions

(2015) Julia Marschallinger et al.   CELL CALCIUM

Lewy body dementias

(2015) Zuzana Walker et al.   LANCET

Neuroinflammation in Lewy body dementia

(2015) Ajenthan Surendranathan et al.   PARKINSONISM & RELATED DISORDERS

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

(2015) Julia Marschallinger et al.   Nature Communications

Gene-Wise Association of Variants in Four Lysosomal Storage Disorder Genes in Neuropathologically Confirmed Lewy Body Disease

(2015) Lorraine N. Clark et al.   PLoS One

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

The neurobiological basis of cognitive impairment in Parkinson's disease

(2014) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Montelukast rescues primary neurons against Aβ1–42-induced toxicity through inhibiting CysLT1R-mediated NF-κB signaling

(2014) Jin’e Lai et al.   NEUROCHEMISTRY INTERNATIONAL

Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity

(2014) Martin Regensburger et al.   NEURAL PLASTICITY

Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment

(2013) Daniel Lindqvist et al.   BRAIN BEHAVIOR AND IMMUNITY

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease

(2013) P F Giannopoulos et al.   MOLECULAR PSYCHIATRY

Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats

(2013) Ihab T. Abdel-Raheem et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protection of dopaminergic neurons by 5-lipoxygenase inhibitor

(2013) Kai-Hsiang Kang et al.   NEUROPHARMACOLOGY

Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles

(2013) Jin Chu et al.   PLoS One

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle

(2013) Stefano Fogli et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Inhibitory effects of Montelukast on mediator release by nasal epithelial cells from asthmatic subjects with or without allergic rhinitis

(2013) A. Scaife et al.   RESPIRATORY MEDICINE

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats†

(2012) Fadhil G. Al-Amran et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Montelukast abrogates rhabdomyolysis-induced acute renal failure via rectifying detrimental changes in antioxidant profile and systemic cytokines and apoptotic factors production

(2012) Mai M. Helmy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability

(2012) V.P. Chou et al.   NEUROSCIENCE

Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats

(2012) Anil Kumar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

(2012) Cleopatra Kozlowski et al.   PLoS One

Non-Motor Symptoms in Patients with Parkinson’s Disease – Correlations with Inflammatory Cytokines in Serum

(2012) Daniel Lindqvist et al.   PLoS One

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model

(2011) Jin Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy in Dementias

(2011) Christine Lund Kragh et al.   BRAIN PATHOLOGY

Inhibition of Leukotriene Receptors Boosts Neural Progenitor Proliferation

(2011) Christophe Huber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Cytosolic Phospholipase A 2 -Initiated Lipid Mediator Pathway Induces Autophagy in Macrophages

(2011) Hai-Yan Qi et al.   JOURNAL OF IMMUNOLOGY

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease

(2011) Klaus Seppi et al.   MOVEMENT DISORDERS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart, Liver, Lungs, and Kidneys in a Rat Model of Cecal Ligation and Puncture–Induced Sepsis

(2011) Ali Kagan Coskun et al.   TheScientificWorldJOURNAL

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats

(2010) H. Kalonia et al.   NEUROSCIENCE

Anti-atherogenic effects of montelukast associated with reduced MCP-1 expression in a rabbit carotid balloon injury model

(2008) Song Ge et al.   ATHEROSCLEROSIS

Peripheral cytokines profile in Parkinson’s disease

(2008) M. Reale et al.   BRAIN BEHAVIOR AND IMMUNITY

Montelukast inhibits tumour necrosis factor-α-mediated interleukin-8 expression through inhibition of nuclear factor-κB p65-associated histone acetyltransferase activity

(2008) F. Tahan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effects of zileuton and montelukast in mouse experimental spinal cord injury

(2007) T Genovese et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL