Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
出版年份 2020 全文链接
标题
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
作者
关键词
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出版物
NATURE NEUROSCIENCE
Volume 23, Issue 2, Pages 194-208
出版商
Springer Science and Business Media LLC
发表日期
2020-01-21
DOI
10.1038/s41593-019-0566-1
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
- (2019) John V. Pluvinage et al. NATURE
- Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
- (2019) Hanadie Yousef et al. NATURE MEDICINE
- Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
- (2019) Diego Adhemar Jaitin et al. CELL
- Role of metabolic programming in the modulation of microglia phagocytosis by lipids
- (2018) A. Nadjar PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Defective cholesterol clearance limits remyelination in the aged central nervous system
- (2018) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Lipid Droplets as Immune Modulators in Myeloid Cells
- (2018) Martijn H. den Brok et al. TRENDS IN IMMUNOLOGY
- Progranulin in the hematopoietic compartment protects mice from atherosclerosis
- (2018) Andrew D. Nguyen et al. ATHEROSCLEROSIS
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing
- (2018) Qingyun Li et al. NEURON
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases
- (2017) Xirong Hu et al. NEUROCHEMICAL RESEARCH
- Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
- (2017) Christopher J. Bohlen et al. NEURON
- Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
- (2017) David W. Morgens et al. Nature Communications
- Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
- (2017) Bret M. Evers et al. Cell Reports
- S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
- (2016) Pingting Liu et al. Disease Models & Mechanisms
- Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
- (2016) Richard M Deans et al. Nature Chemical Biology
- New tools for studying microglia in the mouse and human CNS
- (2016) Mariko L. Bennett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes
- (2016) Marilia Kimie Shimabukuro et al. Scientific Reports
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
- (2015) Lucy Liu et al. CELL
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
- (2015) Angelika S. Rambold et al. DEVELOPMENTAL CELL
- Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
- (2015) Philip Chang et al. Journal of Neuroinflammation
- Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
- (2015) Inge R Holtman et al. Acta Neuropathologica Communications
- Lipopolysaccharide-Stimulated Transglutaminase 2 Expression Enhances Endocytosis Activity in the Mouse Microglial Cell Line BV-2
- (2015) Kenji Kawabe et al. NEUROIMMUNOMODULATION
- Microglial dysfunction in brain aging and Alzheimer's disease
- (2014) Kira Irving Mosher et al. BIOCHEMICAL PHARMACOLOGY
- Shedding new light on lipid functions with CARS and SRS microscopy
- (2014) Yong Yu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
- (2014) E. Tsika et al. HUMAN MOLECULAR GENETICS
- Cellular Fatty Acid Metabolism and Cancer
- (2013) Erin Currie et al. Cell Metabolism
- Microglia: Scapegoat, Saboteur, or Something Else?
- (2013) A. Aguzzi et al. SCIENCE
- A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
- (2013) Isaac M. Chiu et al. Cell Reports
- Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia
- (2012) Armen Khatchadourian et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- BODIPY dyes in photodynamic therapy
- (2012) Anyanee Kamkaew et al. CHEMICAL SOCIETY REVIEWS
- Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4
- (2012) Z. Chen et al. JOURNAL OF NEUROSCIENCE
- Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways
- (2011) Giulia Chinetti-Gbaguidi et al. CIRCULATION RESEARCH
- Core features of frontotemporal dementia recapitulated in progranulin knockout mice
- (2011) N. Ghoshal et al. NEUROBIOLOGY OF DISEASE
- Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4–Synthesizing Lipid Bodies
- (2010) Adriana Vieira-de-Abreu et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Lipids in Alzheimer's disease: A century-old story
- (2010) Paul Foley BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia
- (2010) Fangfang Yin et al. FASEB JOURNAL
- Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
- (2010) Prakash G. Chandak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid droplets in inflammation and cancer
- (2010) Patricia T. Bozza et al. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes
- (2008) Jiyeon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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