Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes

(2019) Danica W. Ito et al.   JOURNAL OF PHYSIOLOGY-LONDON

RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome

(2019) Nadjet Belbachir et al.   EUROPEAN HEART JOURNAL

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

(2018) Sam Chai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

(2018) Lin Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons

(2017) Alessandra Folci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic cleavage and PKA phosphorylation of α1Csubunit are not required for adrenergic regulation of CaV1.2 in the heart

(2017) Alexander Katchman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Quantitative mass spectrometry-based multiplexing compares the abundance of 5000 S. cerevisiae proteins across 10 carbon sources

(2016) Joao A. Paulo et al.   Journal of Proteomics

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

(2016) Victoria Hung et al.   Nature Protocols

The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition

(2016) Eric W. Deutsch et al.   NUCLEIC ACIDS RESEARCH

Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart

(2016) Bryana M. Levitan et al.   Journal of Cardiovascular Translational Research

Uncovering Aberrant Mutant PKA Function with Flow Cytometric FRET

(2016) Shin-Rong Lee et al.   Cell Reports

Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs

(2015) Matthew J. Bailey et al.   DEVELOPMENTAL CELL

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

(2015) Elaine Wan et al.   JOURNAL OF CLINICAL INVESTIGATION

Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in CaV1.2 channel regulation

(2015) Donald D. Chang et al.   JOURNAL OF PHYSIOLOGY-LONDON

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Apocalmodulin Itself Promotes Ion Channel Opening and Ca2+ Regulation

(2014) Paul J. Adams et al.   CELL

The PDZ Motif of the α1CSubunit Is Not Required for Surface Trafficking and Adrenergic Modulation of CaV1.2 Channel in the Heart

(2014) Lin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

β-Adrenergic Regulation of the L-type Ca 2+ Channel Does Not Require Phosphorylation of α 1C Ser 1700

(2013) Lin Yang et al.   CIRCULATION RESEARCH

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Rad GTPase Deletion Increases L‐type Calcium Channel Current Leading to Increased Cardiac Contraction

(2013) Janet R. Manning et al.   Journal of the American Heart Association

Deletion of the C-terminal Phosphorylation Sites in the Cardiac β-Subunit Does Not Affect the Basic β-Adrenergic Response of the Heart and the Cav1.2 Channel

(2012) Julia Brandmayr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells

(2012) Satyajit Mahapatra et al.   JOURNAL OF PHYSIOLOGY-LONDON

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

Distinct RGK GTPases Differentially Use α1- and Auxiliary β-Binding-Dependent Mechanisms to Inhibit CaV1.2/CaV2.2 Channels

(2012) Tingting Yang et al.   PLoS One

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited Ca V 1.2 Channels in Heart

(2010) Xianghua Xu et al.   CIRCULATION RESEARCH

Cardiac L-type calcium channel (Cav1.2) associates with γ subunits

(2010) Lin Yang et al.   FASEB JOURNAL

Molecular Mechanism of Calcium Channel Regulation in the Fight-or-Flight Response

(2010) M. D. Fuller et al.   Science Signaling

Protein Kinase C Isoforms Differentially Phosphorylate Cav1.2 α1c

(2009) Lin Yang et al.   BIOCHEMISTRY

Rad As a Novel Regulator of Excitation–Contraction Coupling and β-Adrenergic Signaling in Heart

(2009) Gang Wang et al.   CIRCULATION RESEARCH

Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Cav1.2 Phosphorylation Site S1928A Mutant Mice

(2008) Toni Lemke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY