Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

Proteolytic cleavage and PKA phosphorylation of α1Csubunit are not required for adrenergic regulation of CaV1.2 in the heart

(2017) Alexander Katchman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

(2015) Jorge A. Negroni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

β-Adrenergic Regulation of the L-type Ca 2+ Channel Does Not Require Phosphorylation of α 1C Ser 1700

(2013) Lin Yang et al.   CIRCULATION RESEARCH

The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia

(2013) Dongyu Min et al.   NEUROSCIENCE LETTERS

Deletion of the C-terminal Phosphorylation Sites in the Cardiac β-Subunit Does Not Affect the Basic β-Adrenergic Response of the Heart and the Cav1.2 Channel

(2012) Julia Brandmayr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Subunits Promote the Expression of CaV2.2 Channels by Reducing Their Proteasomal Degradation

(2011) Dominic Waithe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the Distal C Terminus of CaV1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failurein Vivo

(2011) Ying Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of thecacnb2Gene

(2011) Marcel Meissner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth

(2011) Katrin Domes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of auxiliaryβ-subunit-mediated membrane targeting of L-type (CaV1.2) channels

(2011) Kun Fang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and β-adrenergic reserve of hearts with increased Cav1.2 activity

(2010) Mingxin Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited Ca V 1.2 Channels in Heart

(2010) Xianghua Xu et al.   CIRCULATION RESEARCH

Ryanodine receptor studies using genetically engineered mice

(2010) Alexander Kushnir et al.   FEBS LETTERS

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

(2010) Xiongwen Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

(2010) Christophe Altier et al.   NATURE NEUROSCIENCE

The β Subunit of Voltage-Gated Ca2+ Channels

(2010) Zafir Buraei et al.   PHYSIOLOGICAL REVIEWS

Role of CaMKII  phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure

(2010) A. Kushnir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice

(2009) Nadine Beetz et al.   CARDIOVASCULAR RESEARCH

Reciprocal Interactions Regulate Targeting of Calcium Channel β Subunits and Membrane Expression of α1Subunits in Cultured Hippocampal Neurons

(2009) Gerald J. Obermair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation

(2009) Felix Findeisen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Role of Ca V β Subunits, and Lack of Functional Reserve, in Protein Kinase A Modulation of Cardiac Ca V 1.2 Channels

(2008) Jayalakshmi Miriyala et al.   CIRCULATION RESEARCH

Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Cav1.2 Phosphorylation Site S1928A Mutant Mice

(2008) Toni Lemke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

(2008) D.A. Eisner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

(2008) J. A. Muraski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the CaVα1 AID-CaVβ Interaction Site that Is Critical for Channel Modulation

(2008) Filip Van Petegem et al.   STRUCTURE