Primary chondrocyte exosomes mediate osteoarthritis progression by regulating mitochondrion and immune reactivity

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

(2018) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

(2018) Mitchell C. Coleman et al.   Science Translational Medicine

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells

(2018) Kenneth P. Hough et al.   Redox Biology

Cartilaginous Metabolomic Study Reveals Potential Mechanisms of Osteophyte Formation in Osteoarthritis

(2017) Zhongwei Xu et al.   JOURNAL OF PROTEOME RESEARCH

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The host response to naturally-derived extracellular matrix biomaterials

(2017) Aaron H. Morris et al.   SEMINARS IN IMMUNOLOGY

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

(2017) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Cellular senescence in aging and osteoarthritis

(2016) Wei Seong Toh et al.   Acta Orthopaedica

Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy

(2016) Pengfei Chen et al.   BIOMATERIALS

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro , but not inhibited directly by anti-inflammatory (M2) macrophages

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Bone Marrow Mesenchymal Stem Cell-Based Engineered Cartilage Ameliorates Polyglycolic Acid/Polylactic Acid Scaffold-Induced Inflammation Through M2 Polarization of Macrophages in a Pig Model

(2016) Jinping Ding et al.   Stem Cells Translational Medicine

Injurious Loading of Articular Cartilage Compromises Chondrocyte Respiratory Function

(2016) Mitchell C. Coleman et al.   Arthritis & Rheumatology

Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury

(2015) Dylan Burger et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Single intra-articular dexamethasone injection immediately post-surgery in a rabbit model mitigates early inflammatory responses and post-traumatic osteoarthritis-like alterations

(2015) Bryan J. Heard et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

(2015) Martin Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial respiration and redox coupling in articular chondrocytes

(2015) Rachel S Lane et al.   ARTHRITIS RESEARCH & THERAPY

Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice

(2015) Paxton M. Moon et al.   Current Rheumatology Reports

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Biosynthesis of collagen I, II, RUNX2 and lubricin at different time points of chondrogenic differentiation in a 3D in vitro model of human mesenchymal stem cells derived from adipose tissue

(2014) Giuseppe Musumeci et al.   ACTA HISTOCHEMICA

Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions

(2014) Ali Mobasheri et al.   MATURITAS

The role of mitochondrial reactive oxygen species in cartilage matrix destruction

(2014) Kendra N. Reed et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

Anti-Inflammatory Strategies in Cartilage Repair

(2014) Ying Zhang et al.   TISSUE ENGINEERING PART B-REVIEWS

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Clinical Outcomes After Cell-Seeded Autologous Chondrocyte Implantation of the Knee

(2013) Jan M. Pestka et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury

(2013) C.M. Haslauer et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation

(2013) Ruenn Chai Lai et al.   Regenerative Medicine

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes

(2008) V.I. Grishko et al.   OSTEOARTHRITIS AND CARTILAGE