Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance

Unveiling a Single-Metal-Mediated Phosphodiester Bond Cleavage Mechanism for Nucleic Acids: A Multiscale Computational Investigation of a Human DNA Repair Enzyme

(2019) Mohamed M. Aboelnga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

(2019) Vinod Tiwari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1

(2019) Milena Bazlekowa-Karaban et al.   DNA REPAIR

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

(2018) Elizabeth T. Abshire et al.   NUCLEIC ACIDS RESEARCH

APE1 deficiency promotes cellular senescence and premature aging features

(2018) Mengxia Li et al.   NUCLEIC ACIDS RESEARCH

Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II

(2018) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

(2018) Amy M. Whitaker et al.   Nature Communications

Eukaryotic translesion synthesis: Choosing the right tool for the job

(2018) Kyle T. Powers et al.   DNA REPAIR

APE1: A skilled nucleic acid surgeon

(2018) Amy M. Whitaker et al.   DNA REPAIR

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

(2018) Jianfeng Li et al.   Oncotarget

Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5′ mismatches

(2018) Max S. Fairlamb et al.   Acta Crystallographica Section D-Structural Biology

Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors

(2018) Lavinia C. Dumitrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes

(2017) Jennifer L. Illuzzi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Base excision repair of oxidative DNA damage from mechanism to disease

(2017) Bret D Freudenthal   Frontiers in Bioscience-Landmark

Mechanisms of DNA–protein crosslink repair

(2017) Julian Stingele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA–Protein Crosslink Proteolysis Repair

(2017) Bruno Vaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

(2016) David Lopez-Martinez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Base Excision Repair, a Pathway Regulated by Posttranslational Modifications

(2016) Rachel J. Carter et al.   MOLECULAR AND CELLULAR BIOLOGY

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury

(2016) R. Anne Stetler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation

(2016) Lisa Lirussi et al.   Oncotarget

A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions

(2015) S. Thakur et al.   CELL BIOCHEMISTRY AND FUNCTION

Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase η

(2015) Amritaj Patra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts with apurinic/apyrimidinic sites in DNA

(2015) Anastasiya A. Kosova et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enzyme mechanism-based, oxidative DNA–protein cross-links formed with DNA polymerase β in vivo

(2015) Jason L. Quiñones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Base excision repair capacity in informing healthspan

(2014) B. M. Brenerman et al.   CARCINOGENESIS

Looking beneath the surface to determine what makes DNA damage deleterious

(2014) Marc M Greenberg   CURRENT OPINION IN CHEMICAL BIOLOGY

Interstrand DNA–DNA Cross-Link Formation Between Adenine Residues and Abasic Sites in Duplex DNA

(2014) Nathan E. Price et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences

(2014) Savithri Weerasooriya et al.   PLoS One

Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example

(2013) Giulia Antoniali et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes

(2013) Susan E. Tsutakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination

(2013) S. Masani et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Assessment of Population and Tumor-Associated APE1 Protein Variants

(2013) Jennifer L. Illuzzi et al.   PLoS One

Recent advances in the structural mechanisms of DNA glycosylases

(2012) Sonja C. Brooks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease

(2011) Meihua Luo et al.   BIOCHEMISTRY

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Lys98 Substitution in Human AP Endonuclease 1 Affects the Kinetic Mechanism of Enzyme Action in Base Excision and Nucleotide Incision Repair Pathways

(2011) Nadezhda A. Timofeyeva et al.   PLoS One

Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin

(2010) Hua Fung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Mitochondrial Targeting Sequence of Human Apurinic/Apyrimidinic Endonuclease 1

(2010) Mengxia Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)

(2010) S. N. Khodyreva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

(2009) V. M. Castillo-Acosta et al.   NUCLEIC ACIDS RESEARCH

Ku antigen interacts with abasic sites

(2008) Ekaterina S. Ilina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

(2008) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

(2008) M.M. Georgiadis et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The roles of APE1, APE2, DNA polymerase   and mismatch repair in creating S region DNA breaks during antibody class switch

(2008) C. E Schrader et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES