Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

(2016) C. Lachaud et al.   SCIENCE

Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia

(2015) Asuka Hira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection

(2015) Balaji Parameswaran et al.   CELL CYCLE

FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex

(2015) Maya Raghunandan et al.   CELL CYCLE

Regulation of the Rev1-pol   complex during bypass of a DNA interstrand cross-link

(2015) M. Budzowska et al.   EMBO JOURNAL

AluY-mediated germline deletion, duplication and somatic stem cell reversion inUBE2Tdefines a new subtype of Fanconi anemia

(2015) Elizabeth L. Virts et al.   HUMAN MOLECULAR GENETICS

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

(2015) Jennifer A. Miles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway

(2015) Jenny Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia

(2015) Kimberly A. Rickman et al.   Cell Reports

UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

(2015) Chih-Chao Liang et al.   Cell Reports

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

(2015) Yanyan Tian et al.   Cell Reports

The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

(2014) Helen Walden et al.   Annual Review of Biophysics

Aromatic Nitrogen Mustard-Based Prodrugs: Activity, Selectivity, and the Mechanism of DNA Cross-Linking

(2014) Wenbing Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

NMR Structure of an Ethylene Interstrand Cross-Linked DNA which Mimics the Lesion Formed by 1,3-Bis(2-chloroethyl)-1-nitrosourea

(2014) Derek K. O'Flaherty et al.   ChemMedChem

Fanconi anaemia: genetics, molecular biology, and cancer - implications for clinical management in children and adults

(2014) M. Schneider et al.   CLINICAL GENETICS

Crosstalk between the nucleotide excision repair and Fanconi anemia/BRCA pathways

(2014) Kent W. Mouw et al.   DNA REPAIR

FANCD2-Controlled Chromatin Access of the Fanconi-Associated Nuclease FAN1 Is Crucial for the Recovery of Stalled Replication Forks

(2014) I. Chaudhury et al.   MOLECULAR AND CELLULAR BIOLOGY

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

(2014) Eeson Rajendra et al.   MOLECULAR CELL

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA

(2014) Simonne Longerich et al.   NUCLEIC ACIDS RESEARCH

K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks

(2014) B Zhu et al.   ONCOGENE

FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks

(2014) Olga Murina et al.   Cell Reports

FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair

(2014) Junya Unno et al.   Cell Reports

Modularized Functions of the Fanconi Anemia Core Complex

(2014) Yaling Huang et al.   Cell Reports

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

(2014) Elaine T. Lim et al.   PLoS Genetics

Why does the bone marrow fail in Fanconi anemia?

(2013) J. I. Garaycoechea et al.   BLOOD

ATR-Dependent Phosphorylation of FANCM at Serine 1045 Is Essential for FANCM Functions

(2013) T. R. Singh et al.   CANCER RESEARCH

Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response

(2013) A. N. Suhasini et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

(2013) Jing Huang et al.   MOLECULAR CELL

ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway

(2012) T. Shigechi et al.   CANCER RESEARCH

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Monoubiquitination-dependent chromatin loading of FancD2 in silkworms, a species lacking the FA core complex

(2012) Ryohei Sugahara et al.   GENE

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

(2012) Zhijiang Yan et al.   MOLECULAR CELL

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

(2012) Milica Enoiu et al.   NUCLEIC ACIDS RESEARCH

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI

(2012) K. Sato et al.   NUCLEIC ACIDS RESEARCH

Diepoxybutane interstrand cross-links induce DNA bending

(2011) Julie T. Millard et al.   BIOCHIMIE

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

(2011) Avvaru N Suhasini et al.   EMBO JOURNAL

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

(2011) A. T. Wang et al.   GENES & DEVELOPMENT

Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis

(2011) Songmin Ying et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

(2011) Charlotte Hodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diepoxybutane induces the formation of DNA–DNA rather than DNA–protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells

(2011) Ying Wen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

(2011) K. N. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

(2011) D. T. Long et al.   SCIENCE

Fanconi anemia and Bloom's syndrome crosstalk through FANCJ–BLM helicase interaction

(2011) Avvaru N. Suhasini et al.   TRENDS IN GENETICS

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

(2010) Alfons Meindl et al.   NATURE GENETICS

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

(2010) K. Yoshikiyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

(2010) T. Liu et al.   SCIENCE

Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction

(2009) G. Zhi et al.   CANCER RESEARCH

Topo IIIα and BLM Act within the Fanconi Anemia Pathway in Response to DNA-Crosslinking Agents

(2009) A.W. Hemphill et al.   CYTOGENETIC AND GENOME RESEARCH

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis

(2009) Y. Kee et al.   GENES & DEVELOPMENT

The Fanconi Anemia Protein FANCM Is Controlled by FANCD2 and the ATR/ATM Pathways

(2009) Alexandra Sobeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of Laser-localized DNA Interstrand Cross-links in G1Phase Mammalian Cells

(2009) Parameswary A. Muniandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL

(2009) Simonne Longerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage

(2009) Neil Johnson et al.   MOLECULAR CELL

Fanconi anemia proteins and endogenous stresses

(2009) Qishen Pang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources

(2008) Michael P. Stone et al.   ACCOUNTS OF CHEMICAL RESEARCH

Genetic Predisposition to Breast Cancer: Past, Present, and Future

(2008) Clare Turnbull et al.   Annual Review of Genomics and Human Genetics

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

(2008) N. B. Collins et al.   BLOOD

Fanconi anaemia: new strategies

(2008) C Dufour et al.   BONE MARROW TRANSPLANTATION

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1

(2008) Chengmin Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

(2008) Arno F. Alpi et al.   MOLECULAR CELL

Relationship between DNA lesions, DNA repair and chromosomal damage induced by acetaldehyde

(2008) Claudia Lorenti Garcia et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

(2008) Masamichi Ishiai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY