Mechanisms of DNA–protein crosslink repair

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

(2017) Reeja S. Maskey et al.   NUCLEIC ACIDS RESEARCH

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

(2016) Julian Stingele et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

(2016) Bruno Vaz et al.   MOLECULAR CELL

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks

(2016) Jaime Lopez-Mosqueda et al.   eLife

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial

(2015) Amit M Oza et al.   LANCET ONCOLOGY

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

DNA–protein crosslink repair

(2015) Julian Stingele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA–protein crosslink repair: proteases as DNA repair enzymes

(2015) Julian Stingele et al.   TRENDS IN BIOCHEMICAL SCIENCES

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

(2014) Julian Stingele et al.   CELL

Repair of a DNA-Protein Crosslink by Replication-Coupled Proteolysis

(2014) Julien P. Duxin et al.   CELL

The Spartan Ortholog Maternal Haploid Is Required for Paternal Chromosome Integrity in the Drosophila Zygote

(2014) Laetitia Delabaere et al.   CURRENT BIOLOGY

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

(2014) Fernando Gómez-Herreros et al.   NATURE GENETICS

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

(2014) Davor Lessel et al.   NATURE GENETICS

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

(2014) Benu Brata Das et al.   NUCLEIC ACIDS RESEARCH

Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links

(2013) Toshiaki Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II

(2013) Ali Raoof et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

(2013) Manuel Luís Orta et al.   NUCLEIC ACIDS RESEARCH

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Spartan/C1orf124 is important to prevent UV-induced mutagenesis

(2012) Yuka Machida et al.   CELL CYCLE

T7 RNA Polymerases Backed up by Covalently Trapped Proteins Catalyze Highly Error Prone Transcription

(2012) Toshiaki Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1

(2012) A Y Maslov et al.   ONCOGENE

Nijmegen breakage syndrome (NBS)

(2012) Krystyna H Chrzanowska et al.   Orphanet Journal of Rare Diseases

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

(2012) Jessica J.R. Hudson et al.   Nature Communications

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

(2012) K. C. Lee et al.   Biology Open

Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1

(2011) Heidrun Interthal et al.   BIOCHEMICAL JOURNAL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

(2011) Shar-yin N Huang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 Poisons

(2011) Elizabeth J. Sacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

(2011) Ivan V Rosado et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

(2011) Yong-Wei Zhang et al.   NUCLEIC ACIDS RESEARCH

TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage

(2010) Shih-Chieh Chiang et al.   CELL CYCLE

Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle

(2010) J. T. Sczepanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks

(2009) Bendert de Graaf et al.   DNA REPAIR

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells

(2009) Toshiaki Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia

(2009) Pierre Fenaux et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Ctp1CtIP and Rad32Mre11 Nuclease Activity Are Required for Rec12Spo11 Removal, but Rec12Spo11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions

(2009) E. Hartsuiker et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes

(2008) Chao-Po Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology