A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster

G protein βγ subunits play a critical role in the actions of amphetamine

(2019) J. C. Mauna et al.   Translational Psychiatry

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

(2019) Nicholas G. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations

(2019) Mary Hongying Cheng et al.   NEUROPHARMACOLOGY

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)

(2019) Kuai Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gβγ subunit activation promotes dopamine efflux through the dopamine transporter

(2017) J Garcia-Olivares et al.   MOLECULAR PSYCHIATRY

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT

(2017) Jenny I. Aguilar et al.   NEURON

Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study

(2017) Manon Dubol et al.   NEUROPSYCHOPHARMACOLOGY

The CApillary FEeder Assay Measures Food Intake in Drosophila melanogaster

(2017) Soeren Diegelmann et al.   Jove-Journal of Visualized Experiments

Reward and Aversion

(2016) Hailan Hu   Annual Review of Neuroscience

Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function

(2016) Kristin M. Scaplen et al.   JOURNAL OF NEUROGENETICS

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

(2016) Zachary Freyberg et al.   Nature Communications

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus

(2015) George Khelashvili et al.   ACS Chemical Neuroscience

Role of corticostriatal circuits in context-induced reinstatement of drug seeking

(2015) Nathan J. Marchant et al.   BRAIN RESEARCH

Differential effects of cocaine exposure on the abundance of phospholipid species in rat brain and blood

(2015) Brian S. Cummings et al.   DRUG AND ALCOHOL DEPENDENCE

Gustatory Learning and Processing in theDrosophilaMushroom Bodies

(2015) Colleen Kirkhart et al.   JOURNAL OF NEUROSCIENCE

Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective

(2015) Marco Pignatelli et al.   NEURON

Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding

(2015) Mary Hongying Cheng et al.   Frontiers in Neurology

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

(2015) Etienne Cartier et al.   EBioMedicine

Dopamine Dynamics and Signaling in Drosophila: An Overview of Genes, Drugs and Behavioral Paradigms

(2014) Shinya Yamamoto et al.   EXPERIMENTAL ANIMALS

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein

(2014) Peter J Hamilton et al.   Nature Chemical Biology

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

(2013) P J Hamilton et al.   MOLECULAR PSYCHIATRY

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

(2013) F. Buchmayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

The behavioral pharmacology of anorexigenic drugs in nonhuman primates

(2012) Richard W. Foltin   BEHAVIOURAL PHARMACOLOGY

Phosphatidylinositol 4,5-Biphosphate (PIP2) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure

(2012) George Khelashvili et al.   BIOCHEMISTRY

Activation of Moesin, a Protein That Links Actin Cytoskeleton to the Plasma Membrane, Occurs by Phosphatidylinositol 4,5-bisphosphate (PIP2) Binding Sequentially to Two Sites and Releasing an Autoinhibitory Linker

(2012) Khadija Ben-Aissa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila

(2012) A B Pizzo et al.   MOLECULAR PSYCHIATRY

A Modular Toolset for Recombination Transgenesis and Neurogenetic Analysis of Drosophila

(2012) Ji-Wu Wang et al.   PLoS One

PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells

(2012) Narendra Thapa et al.   Cell Adhesion & Migration

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

A Drosophila model for alcohol reward

(2011) Karla R Kaun et al.   NATURE NEUROSCIENCE

Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression

(2010) M.A. Cervinski et al.   NEUROSCIENCE

Abuse of Amphetamines and Structural Abnormalities in the Brain

(2009) Steven Berman et al.   Annals of the New York Academy of Sciences

Writing Memories with Light-Addressable Reinforcement Circuitry

(2009) Adam Claridge-Chang et al.   CELL

Preferential Ethanol Consumption in Drosophila Models Features of Addiction

(2009) Anita V. Devineni et al.   CURRENT BIOLOGY

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

(2008) B. H. Schott et al.   JOURNAL OF NEUROSCIENCE

Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux

(2008) F. Binda et al.   MOLECULAR PHARMACOLOGY