Tutorial on physiologically based kinetic modeling in molecular nutrition and food research

Hydroquinone PBPK model refinement and application to dermal exposure

(2010) Torka S. Poet et al.   FOOD AND CHEMICAL TOXICOLOGY

Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment

(2010) Melvin E. Andersen et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

Chemical-Specific Adjustment Factors for Intraspecies Variability of Acetone Toxicokinetics Using a Probabilistic Approach

(2010) Anna-Karin Mörk et al.   TOXICOLOGICAL SCIENCES

A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes

(2010) Alicia Paini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors

(2010) K. Schroeder et al.   TOXICOLOGY IN VITRO

Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans

(2009) Donald E. Mager et al.   Drug Metabolism and Pharmacokinetics

Estimation of safe dietary intake levels of acrylamide for humans

(2009) Robert G. Tardiff et al.   FOOD AND CHEMICAL TOXICOLOGY

Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans

(2009) Lisa M. Sweeney et al.   FOOD AND CHEMICAL TOXICOLOGY

Physiologically Based Pharmacokinetics of Zearalenone

(2009) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

In silicomethods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: Implications for risk assessment

(2009) Ivonne M. C. M. Rietjens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Evaluation of Human Interindividual Variation in Bioactivation of Estragole Using Physiologically Based Biokinetic Modeling

(2009) Ans Punt et al.   TOXICOLOGICAL SCIENCES

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

(2009) Ans Punt et al.   TOXICOLOGICAL SCIENCES

A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry

(2008) Justin G. Teeguarden et al.   INHALATION TOXICOLOGY

In vitro measurements of metabolism for application in pharmacokinetic modeling

(2008) John C. Lipscomb et al.   PHARMACOLOGY & THERAPEUTICS

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

(2008) Ans Punt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling

(2008) Ivonne M.C.M. Rietjens et al.   TOXICOLOGY IN VITRO

Application of mode-of-action considerations in human cancer risk assessment

(2008) Gary M. Williams   TOXICOLOGY LETTERS

Development and specification of physiologically based pharmacokinetic models for use in risk assessment

(2007) Rebecca A. Clewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY