The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Authors
Keywords
-
Journal
Molecular Cancer
Volume 19, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-02-28
DOI
10.1186/s12943-020-01172-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner
- (2019) Ruifan Wu et al. Cell Death & Disease
- Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
- (2019) Dali Han et al. NATURE
- Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
- (2019) Yue Huang et al. CANCER CELL
- Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
- (2019) Shiming Peng et al. Science Translational Medicine
- KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA
- (2019) Xiaoyu Cheng et al. OncoTargets and Therapy
- Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
- (2019) Huamin Wang et al. Nature Communications
- Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma
- (2019) Zhuo-Xian Rong et al. Frontiers in Oncology
- Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis
- (2019) Thomas Yau et al. JOURNAL OF HEPATOLOGY
- Sequence-specific m6A demethylation in RNA by FTO fused to RCas9
- (2019) Kristina Rau et al. RNA
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
- (2019) Seungwon Yang et al. Nature Communications
- RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
- (2019) Xinyao Lin et al. Nature Communications
- Single-base mapping of m6A by an antibody-independent method
- (2019) Zhang Zhang et al. Science Advances
- m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7
- (2019) Xinxia Wang et al. Autophagy
- YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation
- (2019) Hao Sheng et al. CARCINOGENESIS
- Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
- (2019) Yongsheng Li et al. Molecular Cancer
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates
- (2019) Xiao-Min Liu et al. Nature Chemical Biology
- DART-seq: an antibody-free method for global m6A detection
- (2019) Kate D. Meyer NATURE METHODS
- A global view of hepatocellular carcinoma: trends, risk, prevention and management
- (2019) Ju Dong Yang et al. Nature Reviews Gastroenterology & Hepatology
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
- (2019) Jiajie Hou et al. Molecular Cancer
- Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues
- (2019) Jun’e Liu et al. MOLECULAR CELL
- m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
- (2019) Yuanhui Mao et al. Nature Communications
- m6A mRNA methylation sustains Treg suppressive functions
- (2018) Jiyu Tong et al. CELL RESEARCH
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation
- (2018) Shun Zhou et al. MOLECULAR CARCINOGENESIS
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Highly parallel direct RNA sequencing on an array of nanopores
- (2018) Daniel R Garalde et al. NATURE METHODS
- Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication
- (2018) Kevin Tsai et al. PLoS Pathogens
- Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs
- (2018) Simone Rauch et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle
- (2018) Hasan Imam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Copper-Catalyzed Radical Cross-Coupling of Redox-Active Oxime Esters, Styrenes, and Boronic Acids
- (2018) Xiao-Ye Yu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors
- (2018) Fei Yan et al. CELL RESEARCH
- Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism
- (2018) Tooru Mizuno Nutrients
- MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein
- (2017) Zhe Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3
- (2017) Lai Wei et al. JOURNAL OF HEPATOLOGY
- Corrigendum: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2017) Xiang Wang et al. NATURE
- m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
- (2017) Hua-Bing Li et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- The cancer epigenome: Concepts, challenges, and therapeutic opportunities
- (2017) Mark A. Dawson SCIENCE
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry
- (2016) Wei Huang et al. ANALYTICAL CHEMISTRY
- N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
- (2016) Nandan S. Gokhale et al. Cell Host & Microbe
- TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication
- (2016) Daniel W H Ho et al. GUT
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage
- (2016) Qi Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Post-transcriptional gene regulation by mRNA modifications
- (2016) Boxuan Simen Zhao et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
- (2016) Hao Du et al. Nature Communications
- 5′ UTR m6A Promotes Cap-Independent Translation
- (2015) Kate D. Meyer et al. CELL
- HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
- (2015) Claudio R. Alarcón et al. CELL
- Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis
- (2015) Chun-Ming Wong et al. HEPATOLOGY
- Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009
- (2015) Zobair M. Younossi et al. HEPATOLOGY
- Dynamic m6A mRNA methylation directs translational control of heat shock response
- (2015) Jun Zhou et al. NATURE
- Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
- (2015) Bastian Linder et al. NATURE METHODS
- m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
- (2015) Shay Geula et al. SCIENCE
- A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing
- (2015) Benoit Moindrot et al. Cell Reports
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
- (2014) Pedro J. Batista et al. Cell Stem Cell
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- (2014) Yang Wang et al. NATURE CELL BIOLOGY
- Gene expression regulation mediated through reversible m6A RNA methylation
- (2014) Ye Fu et al. NATURE REVIEWS GENETICS
- The dynamic epitranscriptome: N6-methyladenosine and gene expression control
- (2014) Kate D. Meyer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- Fat Mass and Obesity-Associated Gene Enhances Oxidative Stress and Lipogenesis in Nonalcoholic Fatty Liver Disease
- (2013) Jianjin Guo et al. DIGESTIVE DISEASES AND SCIENCES
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
- (2013) Sandy Leung-Kuen Au et al. PLoS One
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
- (2012) Hashem B. El-Serag GASTROENTEROLOGY
- Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
- (2012) Sandy Leung-Kuen Au et al. HEPATOLOGY
- Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b
- (2012) Dorothy Ngo-Yin Fan et al. HEPATOLOGY
- Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
- (2012) Baoen Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Medical therapies for hepatocellular carcinoma: a critical view of the evidence
- (2012) Augusto Villanueva et al. Nature Reviews Gastroenterology & Hepatology
- MODOMICS: a database of RNA modification pathways—2013 update
- (2012) Magdalena A. Machnicka et al. NUCLEIC ACIDS RESEARCH
- Infection of Lymphoblastoid Cell Lines by Kaposi's Sarcoma-Associated Herpesvirus: Critical Role of Cell-Associated Virus
- (2011) J. Myoung et al. JOURNAL OF VIROLOGY
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- Regulation of mRNA cap methylation
- (2009) Victoria H. Cowling BIOCHEMICAL JOURNAL
- Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005
- (2009) Sean F. Altekruse et al. JOURNAL OF CLINICAL ONCOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started