Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

(2018) Kristina Busygina et al.   BLOOD

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI

(2018) Phillip L.R. Nicolson et al.   HAEMATOLOGICA

Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation

(2018) I. Induruwa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

How to perform aggregometry and lumi-aggregometry in mouse platelets

(2018) Craig E. Hughes   PLATELETS

Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin

(2018) Mariam Ebrahim et al.   THROMBOSIS AND HAEMOSTASIS

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI

(2018) Phillip L.R. Nicolson et al.   HAEMATOLOGICA

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

(2017) Stephanie E. Lombard et al.   PLATELETS

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

(2016) Rachel A. Rigg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The promises of quantitative systems pharmacology modelling for drug development

(2016) V.R. Knight-Schrijver et al.   Computational and Structural Biotechnology Journal

Ibrutinib Inhibits Platelet Integrin αIIbβ3Outside-In Signaling and Thrombus Stability But Not Adhesion to CollagenSignificance

(2015) Alexander P. Bye et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes

(2015) Henriette Ebsen et al.   MOLECULAR IMMUNOLOGY

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling

(2015) Alice Y. Pollitt et al.   THROMBOSIS AND HAEMOSTASIS

A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications

(2015) F. Mazet et al.   Scientific Reports

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach

(2015) Joanne L. Dunster et al.   PLoS Computational Biology

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions

(2014) M. Levade et al.   BLOOD

Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range

(2014) Marlis Zeiler et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

(2014) Tarek A. Leil et al.   Frontiers in Pharmacology

Tyrosine Phosphorylation on Spleen Tyrosine Kinase (Syk) Is Differentially Regulated in Human and Murine Platelets by Protein Kinase C Isoforms

(2013) Lorena Buitrago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The GPVI – Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times

(2013) Martin Ungerer et al.   PLoS One

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis

(2012) Sakthivel Vaiyapuri et al.   CIRCULATION

Distinct and overlapping functional roles of Src family kinases in mouse platelets

(2012) S. SÉVERIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

(2011) Gaby Wangorsch et al.   BMC Systems Biology

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets

(2010) D. H. Thomas et al.   BLOOD

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

(2008) Majd B. Protty et al.   BIOCHEMICAL JOURNAL