Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation

Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy

(2017) M. Y. Lee et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke

(2016) Isuru Induruwa et al.   International Journal of Stroke

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity

(2015) Eric Maurer et al.   THROMBOSIS AND HAEMOSTASIS

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice

(2012) Tanja Schönberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

(2011) Stéphane Loyau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans

(2011) Martin Ungerer et al.   CIRCULATION

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

(2010) N. Pugh et al.   BLOOD

Impact of glycoprotein VI and platelet adhesion on atherosclerosis—A possible role of fibronectin

(2010) Andreas Bültmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

(2010) Huifang Xu et al.   MATRIX BIOLOGY

Platelet glycoprotein VI (GPVI) for early identification of acute coronary syndrome in patients with chest pain

(2010) Boris Bigalke et al.   THROMBOSIS RESEARCH

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets

(2009) J. C. SPALTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs

(2009) S. M. JUNG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcγRIIa and induce GPVI ectodomain shedding

(2009) Mohammad Al-Tamimi et al.   PLATELETS

Mechanisms of Thrombus Formation

(2008) Bruce Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial

(2007) Harold P. Adams et al.   STROKE