Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease

(2013) Hugo Geerts et al.   Frontiers in Pharmacology

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

(2012) Ashley Strougo et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development

(2011) Balaji M. Agoram et al.   DRUG DISCOVERY TODAY

If we designed airplanes like we design drugs…

(2011) Walter S. Woltosz   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

The Type 1 Diabetes PhysioLab® Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse

(2010) L. Shoda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology