Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways

(2010) Jörg Geiger et al.   ANALYTICAL BIOCHEMISTRY

Characterization of a Novel Interaction Between Vasodilator-Stimulated Phosphoprotein and Abelson Interactor 1 in Human Platelets: A Concerted Computational and Experimental Approach

(2010) Marcus Dittrich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Spatio-temporal modeling of signaling protein recruitment to EGFR

(2010) Ming-yu Hsieh et al.   BMC Systems Biology

A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

(2010) Han Yan et al.   BMC Systems Biology

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

(2010) Naama Geva-Zatorsky et al.   CELL

Regulators of Platelet cAMP Levels: Clinical and Therapeutic Implications

(2010) L. Noe et al.   CURRENT MEDICINAL CHEMISTRY

Antiplatelet drug interactions

(2010) I. S. Mackenzie et al.   JOURNAL OF INTERNAL MEDICINE

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study

(2010) Paola Patrignani et al.   Pharmacogenetics and Genomics

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

(2009) Johannes Witt et al.   BMC Systems Biology

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets

(2009) Roger W. Hunter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing adenylyl cyclases as potential drug targets

(2009) Sandra Pierre et al.   NATURE REVIEWS DRUG DISCOVERY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts

(2008) Yuan James Rao et al.   ACTA PHARMACOLOGICA SINICA

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

(2008) Madelyn S. Hanson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Platelet Protein Interactions

(2008) Marcus Dittrich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acceleration of Cardiovascular Disease by a Dysfunctional Prostacyclin Receptor Mutation

(2008) Eric Arehart et al.   CIRCULATION RESEARCH

Prostacyclin therapies for the treatment of pulmonary arterial hypertension

(2008) M. Gomberg-Maitland et al.   EUROPEAN RESPIRATORY JOURNAL

Cyclic nucleotide analogs as probes of signaling pathways

(2008) Heiko Poppe et al.   NATURE METHODS

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

(2008) L. S. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multiscale model of thrombus development

(2007) Z. Xu et al.   Journal of the Royal Society Interface