One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All

Serine Metabolism Supports Macrophage IL-1β Production

(2019) Arianne E. Rodriguez et al.   Cell Metabolism

Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis

(2019) Wei-Chen Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis

(2019) Tho X. Pham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

(2019) Ning Ma et al.   MEDICINAL RESEARCH REVIEWS

Determinants of fibrosis progression and regression in NASH

(2018) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance

(2018) Jun Namkung et al.   Diabetes & Metabolism Journal

Nuclear Folate Metabolism

(2018) Martha S. Field et al.   Annual Review of Nutrition

Folic Acid Supplementation Attenuates Chronic Hepatic Inflammation in High-Fat Diet Fed Mice

(2018) Victoria Sid et al.   LIPIDS

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA

(2018) Judith R. Alonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

(2018) Wonsuk Choi et al.   Nature Communications

Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria

(2017) Tomas Majtan et al.   FASEB JOURNAL

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

Dietary creatine supplementation lowers hepatic triacylglycerol by increasing lipoprotein secretion in rats fed high-fat diet

(2017) Robin P. da Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

Reversible severe fatty liver induced by capecitabine

(2017) Yiyan Jiang et al.   MEDICINE

Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N -methyltransferase is a consequence rather than a cause of liver injury in homocystinuria

(2017) René L. Jacobs et al.   MOLECULAR GENETICS AND METABOLISM

1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver

(2017) Amy Karol Walker   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings

(2016) Rafael Deminice et al.   AMINO ACIDS

Formate: The Neglected Member of One-Carbon Metabolism

(2016) Margaret E. Brosnan et al.   Annual Review of Nutrition

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Pharmacological management of nonalcoholic fatty liver disease

(2016) Diana Barb et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Asymmetric Dimethylarginine and Hepatic Encephalopathy: Cause, Effect or Association?

(2016) Anna Czarnecka et al.   NEUROCHEMICAL RESEARCH

Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice

(2016) Judith Sommer et al.   Oncotarget

Decision on folic acid fortification in Europe must consider both risks and benefits

(2016) A David Smith et al.   BMJ-British Medical Journal

Decision on folic acid fortification in Europe must consider both risks and benefits

(2016) A David Smith et al.   BMJ-British Medical Journal

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

(2015) Karen E Christensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

(2015) Rafael Deminice et al.   AMINO ACIDS

Increased Plasma Levels of Asymmetric Dimethylarginine in Nonalcoholic Fatty Liver Disease

(2015) Salih Boga et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism

(2015) Rafael Deminice et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulation of systemic energy homeostasis by serotonin in adipose tissues

(2015) Chang-Myung Oh et al.   Nature Communications

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation

(2014) Robin P. da Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Platelet-derived serotonin: Translational implications for liver regeneration

(2014) Mickaël Lesurtel et al.   HEPATOLOGY

In VivoKinetics of Formate Metabolism in Folate-deficient and Folate-replete Rats

(2014) Gregory P. Morrow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-alcoholic fatty liver disease: What the clinician needs to know

(2014) Mariana Verdelho Machado   WORLD JOURNAL OF GASTROENTEROLOGY

Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2014) Giovanni Musso et al.   PLOS MEDICINE

Novel insights on interactions between folate and lipid metabolism

(2013) Robin P. da Silva et al.   BIOFACTORS

Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches

(2013) Romina Lomonaco et al.   DRUGS

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

(2013) Igor P. Pogribny et al.   FASEB JOURNAL

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

(2013) Maite Martínez-Uña et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation

(2012) Cecile Martel et al.   HEPATOLOGY

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility

(2012) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Reduced Serotonin Reuptake Transporter (SERT) Function Causes Insulin Resistance and Hepatic Steatosis Independent of Food Intake

(2012) Xiaoning Chen et al.   PLoS One

Folate Biosynthesis, Turnover, and Transport in Plants

(2011) Andrew D. Hanson et al.   Annual Review of Plant Biology

The developing clinical problem of chemotherapy-induced hepatic injury

(2011) Charles H. C. Pilgrim et al.   ANZ JOURNAL OF SURGERY

Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis

(2011) Lorissa J. Niebergall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The ratio of phosphatidylcholine to phosphatidylethanolamine does not predict integrity of growing MT58 Chinese hamster ovary cells

(2011) Lorissa J. Niebergall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

(2011) Ainara Cano et al.   HEPATOLOGY

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

(2011) Rafael Deminice et al.   JOURNAL OF NUTRITION

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Folate status of the population in the Canadian Health Measures Survey

(2010) C. K. Colapinto et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

(2010) Marta Varela-Rey et al.   HEPATOLOGY

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism

(2010) Karen E. Christensen et al.   JOURNAL OF NUTRITION

Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease

(2010) Takhar Kasumov et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

(2009) Yang Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo

(2008) Robin P. da Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients

(2008) Michiel PC Siroen et al.   WORLD JOURNAL OF GASTROENTEROLOGY