Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation

(2015) Qian Gao et al.   AMERICAN JOURNAL OF PATHOLOGY

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

(2015) Rafael Deminice et al.   AMINO ACIDS

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Nonalcoholic fatty liver disease

(2015) Timothy Hardy et al.   CURRENT OPINION IN GASTROENTEROLOGY

PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats

(2015) Yan Zhang et al.   CYTOKINE

The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease

(2015) Daniele Pastori et al.   DIGESTIVE AND LIVER DISEASE

Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine

(2015) Mazen Noureddin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism

(2015) Rafael Deminice et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pharmacotherapy for Nonalcoholic Fatty Liver Disease

(2015) Samer Gawrieh et al.   SEMINARS IN LIVER DISEASE

Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation

(2014) Robin P. da Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study

(2014) Eleonora Scorletti et al.   HEPATOLOGY

Clinical approaches to non-alcoholic fatty liver disease

(2014) Katherine JP Schwenger   WORLD JOURNAL OF GASTROENTEROLOGY

Differential regulation of AMPK activation in leptin- and creatine-deficient mice

(2013) Malte Stockebrand et al.   FASEB JOURNAL

Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: Cause or consequence?

(2013) C. García-Ruiz et al.   FREE RADICAL RESEARCH

Dietary fructose in nonalcoholic fatty liver disease

(2013) Miriam B. Vos et al.   HEPATOLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet

(2013) Ala Al Rajabi et al.   JOURNAL OF NUTRITION

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

(2012) Christiano Robles Rodrigues Alves et al.   AMINO ACIDS

Physiological roles of phosphatidylethanolamine N-methyltransferase

(2012) Dennis E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

l-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome

(2012) Chi-un Choe et al.   HUMAN MOLECULAR GENETICS

The creatine kinase system and pleiotropic effects of creatine

(2011) Theo Wallimann et al.   AMINO ACIDS

The metabolic burden of creatine synthesis

(2011) John T. Brosnan et al.   AMINO ACIDS

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

(2011) Rafael Deminice et al.   JOURNAL OF NUTRITION

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efeitos terapêuticos do treinamento físico em pacientes com doenças reumatológicas pediátricas

(2011) Bruno Gualano et al.   Revista Brasileira De Reumatologia

Fitness versus fatness: Moving beyond weight loss in nonalcoholic fatty liver disease

(2010) Nathan A. Johnson et al.   HEPATOLOGY

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

(2010) Giovanni Musso et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

(2010) Francisco Caballero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

(2009) B. Viollet et al.   Acta Physiologica

Exploring the therapeutic role of creatine supplementation

(2009) Bruno Gualano et al.   AMINO ACIDS

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo

(2008) Robin P. da Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats

(2008) Rafael Deminice et al.   BRITISH JOURNAL OF NUTRITION

Impact of Increased PPARγ Activity in Adipocytes in vivo on Adiposity, Insulin Sensitivity and the Effects of Rosiglitazone Treatment

(2008) Katsuko TAKASAWA et al.   ENDOCRINE JOURNAL

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Sulfur-Amino Acid Metabolism and Oxidative Stress in Nonalcoholic Fatty Liver Are Alleviated by Betaine Supplementation in Rats

(2008) Do Y. Kwon et al.   JOURNAL OF NUTRITION