PKCγ interneurons, a gateway to pathological pain in the dorsal horn

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

(2020) Cedric Peirs et al.   JOURNAL OF NEURAL TRANSMISSION

Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons

(2019) Miriam Candelas et al.   Scientific Reports

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

(2019) Kieran A. Boyle et al.   Cell Reports

Dorsal Horn PKCγ Interneurons Mediate Mechanical Allodynia through 5-HT2AR-Dependent Structural Reorganization

(2019) Tyler S. Nelson   JOURNAL OF NEUROSCIENCE

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

(2018) Ru-Rong Ji et al.   ANESTHESIOLOGY

Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus

(2018) Maria Gutierrez-Mecinas et al.   Brain Structure & Function

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

(2018) Rahul Dhandapani et al.   Nature Communications

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

(2018) Yuanyuan Liu et al.   NATURE

5-HT2A Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat

(2018) Cristina Alba-Delgado et al.   JOURNAL OF NEUROSCIENCE

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn

(2017) Andrew J Todd   Molecular Pain

Neuropeptide Y and its involvement in chronic pain

(2017) Marta Diaz-delCastillo et al.   NEUROSCIENCE

Protein Kinase C γ Interneurons Mediate C-fiber–induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber–induced Nociceptive Behavior

(2016) Cedric Peirs et al.   ANESTHESIOLOGY

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord

(2016) Ming-Dong Zhang et al.   Brain Structure & Function

Lamina specific postnatal development of PKCγ interneurons within the rat medullary dorsal horn

(2016) Noemie Mermet-Joret et al.   Developmental Neurobiology

Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia

(2016) Nathalie Pham-Dang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A quantitative study of neurochemically defined excitatory interneuron populations in laminae I–III of the mouse spinal cord

(2016) Maria Gutierrez-Mecinas et al.   Molecular Pain

Neural circuits for pain: Recent advances and current views

(2016) C. Peirs et al.   SCIENCE

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Dorsal Horn Circuits for Persistent Mechanical Pain

(2015) Cedric Peirs et al.   NEURON

Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord

(2015) L. Huang et al.   NEUROSCIENCE

EphrinB–EphB signaling regulates spinal pain processing via PKCγ

(2015) X.-L. Zhou et al.   NEUROSCIENCE

Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach

(2015) Cristina Alba-Delgado et al.   PAIN

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Ephrins and pain

(2013) Ioanna Vasileiou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs to these neurons, and subcellular localization of the enzyme

(2013) Cédric Peirs et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Novel Population of Cholinergic Neurons in the Macaque Spinal Dorsal Horn of Potential Clinical Relevance for Pain Therapy

(2013) S. A. Pawlowski et al.   JOURNAL OF NEUROSCIENCE

Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities

(2013) Y. Xu et al.   JOURNAL OF NEUROSCIENCE

Transient, 5-HT2B receptor–mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons

(2013) Zigor Aira et al.   PAIN

Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors

(2012) Zigor Aira et al.   PAIN

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

(2012) Hanns Ulrich Zeilhofer et al.   PHYSIOLOGICAL REVIEWS

Isozyme-specific Effects of Protein Kinase C in Pain Modulation

(2011) Chengshui Zhao et al.   ANESTHESIOLOGY

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord

(2011) Bruce Mesnage et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Role of Sensory Fiber Demography in Trigeminal and Postherpetic Neuralgias

(2011) A.F. DaSilva et al.   JOURNAL OF DENTAL RESEARCH

Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K+ channels primarily in excitatory neurons of the spinal dorsal horn

(2011) Hui-Juan Hu et al.   JOURNAL OF NEUROPHYSIOLOGY

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine

(2011) Loïs S. Miraucourt et al.   PAIN

Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release

(2011) June Yowtak et al.   PAIN

Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

(2010) Il-ok Lee et al.   ACTA PHARMACOLOGICA SINICA

Intrathecal Lentiviral-Mediated RNA Interference Targeting PKCγ Attenuates Chronic Constriction Injury–Induced Neuropathic Pain in Rats

(2010) Wangyuan Zou et al.   HUMAN GENE THERAPY

Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn

(2010) Erika Polgár et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Gene knockdown with lentiviral vector-mediated intrathecal RNA interference of protein kinase C gamma reverses chronic morphine tolerance in rats

(2010) Zongbin Song et al.   JOURNAL OF GENE MEDICINE

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach

(2010) Toshiharu Yasaka et al.   PAIN

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice

(2009) Ya-Yun Wang et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Glycine Inhibitory Dysfunction Induces a Selectively Dynamic, Morphine-Resistant, and Neurokinin 1 Receptor- Independent Mechanical Allodynia

(2009) L. S. Miraucourt et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Different Forms of Glycine- and GABAA-Receptor Mediated Inhibitory Synaptic Transmission in Mouse Superficial and Deep Dorsal Horn Neurons

(2009) Wayne B Anderson et al.   Molecular Pain

Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors

(2009) Rebecca P. Seal et al.   NATURE

Regional Differences in the Decay Kinetics of GABAA Receptor-Mediated Miniature IPSCs in the Dorsal Horn of the Rat Spinal Cord Are Determined by Mitochondrial Transport of Cholesterol

(2008) P. Inquimbert et al.   JOURNAL OF NEUROSCIENCE

Innocuous, Not Noxious, Input Activates PKC  Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

(2008) S. Neumann et al.   JOURNAL OF NEUROSCIENCE

Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat

(2008) A.S. Hughes et al.   NEUROSCIENCE

Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice

(2008) Erica S. Schwartz et al.   PAIN