Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

(2019) Mariantonia Logozzi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

(2019) Mariantonia Logozzi et al.   Cancers

A Pilot Clinical Study on the Prognostic Relevance of Plasmatic Exosomes Levels in Oral Squamous Cell Carcinoma Patients

(2019) Samuel Rodríguez Zorrilla et al.   Cancers

Extracellular acidity and increased exosome release as key phenotypes of malignant tumors

(2019) Mariantonia Logozzi et al.   CANCER AND METASTASIS REVIEWS

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

(2019) Hedlund et al.   Cancers

The key role of extracellular vesicles in the metastatic process

(2018) Hongyun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

(2018) Claudiu T. Supuran et al.   MEDICINAL RESEARCH REVIEWS

Carbonic anhydrase IX is a prognostic biomarker in glioblastoma multiforme

(2018) Bulent Cetin et al.   NEUROPATHOLOGY

A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis

(2018) Enrico Spugnini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes

(2018) Mariantonia Logozzi et al.   Cancers

Plasmatic carbonic anhydrase IX as a diagnostic marker for clear cell renal cell carcinoma

(2017) Laura Lucarini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors

(2017) Elisabetta Iessi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

(2017) Katsuyuki Kusuzaki et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

(2017) Elena Andreucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Precise and diffraction-limited waveguide-to-free-space focusing gratings

(2017) Karan K. Mehta et al.   Scientific Reports

The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

(2016) Brian P. Mahon et al.   BIOCHEMISTRY

Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer

(2016) Maria Raffaella Ambrosio et al.   Diagnostic Pathology

A nonmainstream approach against cancer

(2016) Stefano Fais   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Proton channels and exchangers in cancer

(2015) Enrico Pierluigi Spugnini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach

(2015) Sophie Taylor et al.   DRUG RESISTANCE UPDATES

Carbonic anhydrase IX inhibitors in cancer therapy: an update

(2015) Claudiu T Supuran et al.   Future Medicinal Chemistry

Roles of Carbonic Anhydrase IX in Development of Pancreatic Cancer

(2015) Yuji Li et al.   PATHOLOGY & ONCOLOGY RESEARCH

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

(2014) Stefano Fais et al.   CANCER AND METASTASIS REVIEWS

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Exosomes released in vitro from Epstein–Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs

(2013) Andrea Canitano et al.   CANCER LETTERS

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates

(2011) Stefano Fais et al.   TRENDS IN MOLECULAR MEDICINE

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE