Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome

Electrostatics and Intrinsic Disorder Drive Translocon Binding of the SRP Receptor FtsY

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Toward a structural understanding of co-translational protein translocation

(2016) Rebecca M Voorhees et al.   CURRENT OPINION IN CELL BIOLOGY

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

(2016) Klemens Wild et al.   JOURNAL OF MOLECULAR BIOLOGY

The bacterial SRP receptor, FtsY, is activated on binding to the translocon

(2016) Albena Draycheva et al.   MOLECULAR MICROBIOLOGY

Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction

(2016) Matthias M. M. Becker et al.   NUCLEIC ACIDS RESEARCH

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

(2016) Ahmad Jomaa et al.   Nature Communications

Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon

(2015) Patrick Kuhn et al.   JOURNAL OF CELL BIOLOGY

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

(2015) Bertrand Beckert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome–SRP–FtsY cotranslational targeting complex in the closed state

(2015) Ottilie von Loeffelholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Signal-sequence induced conformational changes in the signal recognition particle

(2015) Tobias Hainzl et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

(2015) Bertrand Beckert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State

(2015) Yoshiki Tanaka et al.   Cell Reports

Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length

(2014) Thomas R. Noriega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting

(2014) Ishu Saraogi et al.   JOURNAL OF CELL BIOLOGY

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

(2014) Kärt Denks et al.   MOLECULAR MEMBRANE BIOLOGY

SRP RNA Remodeling by SRP68 Explains Its Role in Protein Translocation

(2014) J. T. Grotwinkel et al.   SCIENCE

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

Molecular Mechanism of GTPase Activation at the Signal Recognition Particle (SRP) RNA Distal End

(2013) Kuang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

(2013) David Akopian et al.   JOURNAL OF CELL BIOLOGY

Influence of electron dose rate on electron counting images recorded with the K2 camera

(2013) Xueming Li et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNA

(2013) Felix Voigts-Hoffmann et al.   MOLECULAR CELL

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

(2012) Kuang Shen et al.   NATURE

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal sequence–independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle

(2011) David Braig et al.   MOLECULAR BIOLOGY OF THE CELL

Preserving the membrane barrier for small molecules during bacterial protein translocation

(2011) Eunyong Park et al.   NATURE

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor

(2010) Leandro F Estrozi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor

(2008) Benjamin Weiche et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational transition of Sec machinery inferred from bacterial SecYE structures

(2008) Tomoya Tsukazaki et al.   NATURE

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry