The TCR is an allosterically regulated macromolecular machinery changing its conformation while working

How does T cell receptor clustering impact on signal transduction?

(2019) Jesse Goyette et al.   JOURNAL OF CELL SCIENCE

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

(2019) O Sascha Yousefi et al.   eLife

Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

(2019) Doug K Tischer et al.   eLife

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

A window of opportunity for cooperativity in the T Cell Receptor

(2018) N. Martin-Blanco et al.   Nature Communications

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor

(2018) Claudia Juraske et al.   Frontiers in Immunology

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Peptide–MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites

(2018) Sneha Rangarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

(2018) Kristine N. Brazin et al.   IMMUNITY

The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer

(2017) Kerstin Zimmermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ionic CD3−Lck interaction regulates the initiation of T-cell receptor signaling

(2017) Lunyi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensing drives acuity ofαβT-cell recognition

(2017) Yinnian Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

(2017) En Cai et al.   SCIENCE

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

(2017) Kannan Natarajan et al.   Nature Communications

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

T cell activation requires force generation

(2016) Kenneth H. Hu et al.   JOURNAL OF CELL BIOLOGY

The Allostery Model of TCR Regulation

(2016) Wolfgang W. A. Schamel et al.   JOURNAL OF IMMUNOLOGY

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

A conserved αβ transmembrane interface forms the core of a compact T-cell receptor–CD3 structure within the membrane

(2016) Logesvaran Krshnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

(2016) A. Borroto et al.   Science Translational Medicine

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex

(2016) Aswin Natarajan et al.   Cell Reports

Membrane-Mediated Regulation of the Intrinsically Disordered CD3 ϵ Cytoplasmic Tail of the TCR

(2015) Cesar A. López et al.   BIOPHYSICAL JOURNAL

Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?

(2015) Tom C.B. McLeish et al.   BIOPHYSICAL JOURNAL

T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells

(2015) Cecilie Dahl Hem et al.   Cell Communication and Signaling

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR

(2015) Yanan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning

(2015) Pussadee Paensuwan et al.   JOURNAL OF IMMUNOLOGY

Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells

(2015) Jinsung Hong et al.   JOURNAL OF IMMUNOLOGY

Cytoskeletal forces during signaling activation in Jurkat T-cells

(2015) King Lam Hui et al.   MOLECULAR BIOLOGY OF THE CELL

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

(2015) Zheng Liu et al.   NATURE METHODS

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Constitutively Oxidized CXXC Motifs within the CD3 Heterodimeric Ectodomains of the T Cell Receptor Complex Enforce the Conformation of Juxtaposed Segments

(2014) Kristine N. Brazin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proline-Rich Sequence of CD3  as an Amplifier of Low-Avidity TCR Signaling

(2014) P. Tailor et al.   JOURNAL OF IMMUNOLOGY

Relevance of Nck-CD3  Interaction for T Cell Activation In Vivo

(2014) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Membrane Association of the CD3  Signaling Domain Is Required for Optimal T Cell Development and Function

(2014) M. L. Bettini et al.   JOURNAL OF IMMUNOLOGY

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Molecular architecture of the αβ T cell receptor–CD3 complex

(2014) Michael E. Birnbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

(2014) R. Blanco et al.   Science Signaling

The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

(2014) Elaine P. Dopfer et al.   Cell Reports

Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation

(2013) Yair Klieger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Organization of the resting TCR in nanoscale oligomers

(2012) Wolfgang W. A. Schamel et al.   IMMUNOLOGICAL REVIEWS

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism

(2012) W. F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

TCR Signaling Emerges from the Sum of Many Parts

(2012) Michael S. Kuhns et al.   Frontiers in Immunology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Physical and Functional Bivalency Observed Among TCR/CD3 Complexes Isolated from Primary T Cells

(2011) A. G. Schrum et al.   JOURNAL OF IMMUNOLOGY

Basal and Antigen-Induced Exposure of the Proline-Rich Sequence in CD3 

(2011) J. de la Cruz et al.   JOURNAL OF IMMUNOLOGY

The CD3   Subunit Contains a Phosphoinositide-Binding Motif That Is Required for the Stable Accumulation of TCR-CD3 Complex at the Immunological Synapse

(2011) L. M. DeFord-Watts et al.   JOURNAL OF IMMUNOLOGY

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Force Measurements of TCR/pMHC Recognition at T Cell Surface

(2011) Pierre-Henri Puech et al.   PLoS One

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

(2011) O. Dushek et al.   Science Signaling

Response Multilayered Control of T Cell Receptor Phosphorylation

(2010) Etienne Gagnon et al.   CELL

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Structural characterization of the TCR complex by electron microscopy

(2010) Ignacio Arechaga et al.   INTERNATIONAL IMMUNOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Fast on-rates allow short dwell time ligands to activate T cells

(2010) C. C. Govern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane binding mode of intrinsically disordered cytoplasmic domains of T cell receptor signaling subunits depends on lipid composition

(2009) Alexander B. Sigalov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

(2009) Travis Beddoe et al.   IMMUNITY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytoplasmic Tail of the T Cell Receptor CD3   Subunit Contains a Phospholipid-Binding Motif that Regulates T Cell Functions

(2009) L. M. DeFord-Watts et al.   JOURNAL OF IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling

(2009) Yibing Wang et al.   PLOS BIOLOGY

Interaction between the N-terminal SH3 domain of Nckα and CD3ɛ-derived peptides: Non-canonical and canonical recognition motifs

(2008) Clara M. Santiveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

The short length of the extracellular domain of ζ is crucial for T cell antigen receptor function

(2008) Susana Minguet et al.   IMMUNOLOGY LETTERS

The extracellular part of ζ is buried in the T cell antigen receptor complex

(2008) Susana Minguet et al.   IMMUNOLOGY LETTERS

Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

(2008) Koh Takeuchi et al.   JOURNAL OF MOLECULAR BIOLOGY

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

(2008) Michaël Mingueneau et al.   NATURE IMMUNOLOGY

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY

T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked Conformation

(2008) Ruth M. Risueño et al.   PLoS One

A permissive geometry model for TCR–CD3 activation

(2008) Susana Minguet et al.   TRENDS IN BIOCHEMICAL SCIENCES

The receptor deformation model of TCR triggering

(2007) Zhengyu Ma et al.   FASEB JOURNAL