The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle

(2018) Andrew C. McShan et al.   Nature Chemical Biology

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

(2018) Jie Geng et al.   eLife

Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors

(2017) Charles L. Dulberger et al.   IMMUNITY

Direct evidence for conformational dynamics in major histocompatibility complex class I molecules

(2017) Andy van Hateren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Crystal structure of a TAPBPR–MHC I complex reveals the mechanism of peptide editing in antigen presentation

(2017) Jiansheng Jiang et al.   SCIENCE

Structure of the TAPBPR–MHC I complex defines the mechanism of peptide loading and editing

(2017) Christoph Thomas et al.   SCIENCE

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

(2017) Kannan Natarajan et al.   Nature Communications

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

(2017) Andreas Neerincx et al.   eLife

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

(2017) Athanasios Papakyriakou et al.   Frontiers in Immunology

Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings

(2017) Cory M. Ayres et al.   Frontiers in Immunology

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

(2017) Marek Wieczorek et al.   Frontiers in Immunology

Nowhere to hide: unconventional translation yields cryptic peptides for immune surveillance

(2016) Shelley R. Starck et al.   IMMUNOLOGICAL REVIEWS

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

(2016) Wilfredo F Garcia-Beltran et al.   NATURE IMMUNOLOGY

Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing

(2016) Giora I. Morozov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress in protein crystallography

(2016) Zbigniew Dauter et al.   PROTEIN AND PEPTIDE LETTERS

Present Yourself! By MHC Class I and MHC Class II Molecules

(2016) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

MHC class II complexes sample intermediate states along the peptide exchange pathway

(2016) Marek Wieczorek et al.   Nature Communications

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex

(2016) Aswin Natarajan et al.   Cell Reports

Structure of the transporter associated with antigen processing trapped by herpes simplex virus

(2016) Michael L Oldham et al.   eLife

HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1

(2016) Aura Burian et al.   PLoS One

Molecular mechanism of peptide editing in the tapasin–MHC I complex

(2016) Olivier Fisette et al.   Scientific Reports

F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins

(2015) Esam T. Abualrous et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR

(2015) Yanan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing transient dark states by NMR spectroscopy

(2015) Nicholas J. Anthis et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Selector function of MHC I molecules is determined by protein plasticity

(2015) Alistair Bailey et al.   Scientific Reports

Molecular Dynamics, Monte Carlo Simulations, and Langevin Dynamics: A Computational Review

(2015) Eric Paquet et al.   Biomed Research International

TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst

(2015) Clemens Hermann et al.   eLife

The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study

(2015) Esam Tolba Abualrous et al.   PLoS One

Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR

(2014) Rina Rosenzweig et al.   Annual Review of Biochemistry

A Glimpse of Structural Biology through X-Ray Crystallography

(2014) Yigong Shi   CELL

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Peptide-dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex

(2014) Saeko Yanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCR Scanning of Peptide/MHC through Complementary Matching of Receptor and Ligand Molecular Flexibility

(2014) W. F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Two Polymorphisms Facilitate Differences in Plasticity between Two Chicken Major Histocompatibility Complex Class I Proteins

(2014) Alistair Bailey et al.   PLoS One

Structural Basis for Recognition of Cellular and Viral Ligands by NK Cell Receptors

(2014) Yili Li et al.   Frontiers in Immunology

The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I–Like Molecules

(2013) Erin J. Adams et al.   Annual Review of Immunology

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Peptide Modulation of Class I Major Histocompatibility Complex Protein Molecular Flexibility and the Implications for Immune Recognition

(2013) William F. Hawse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR spectroscopy reveals unexpected structural variation at the protein–protein interface in MHC class I molecules

(2013) Monika Beerbaum et al.   JOURNAL OF BIOMOLECULAR NMR

Structural and functional mosaic nature of MHC class I molecules in their peptide-free form

(2013) Eiji Kurimoto et al.   MOLECULAR IMMUNOLOGY

Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway

(2013) Louise H. Boyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MHC I loading complex: a multitasking machinery in adaptive immunity

(2013) Sabine Hulpke et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules

(2012) Chee-Seng Hee et al.   IMMUNOGENETICS

Dynamics of Major Histocompatibility Complex Class I Association with the Human Peptide-loading Complex

(2012) Michaela S. Panter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics

(2012) M. G. Mage et al.   JOURNAL OF IMMUNOLOGY

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway

(2011) Monika-Sarah ED Schulze et al.   CURRENT OPINION IN IMMUNOLOGY

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility

(2011) Malgorzata Anna Garstka et al.   FASEB JOURNAL

Dynamical Characterization of Two Differentially Disease Associated MHC Class I Proteins in Complex with Viral and Self-Peptides

(2011) Daniele Narzi et al.   JOURNAL OF MOLECULAR BIOLOGY

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules

(2011) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential glycan-dependent interactions optimize MHC class I peptide loading

(2011) P. A. Wearsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

(2011) C. A. Painter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Routes to manipulate MHC class II antigen presentation

(2010) Tineke van den Hoorn et al.   CURRENT OPINION IN IMMUNOLOGY

Structural Basis of Carbohydrate Recognition by Calreticulin

(2010) Guennadi Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional binding of invariant chain peptides to an MHC class II molecule

(2010) S. Gunther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A General and Efficient Approach for NMR Studies of Peptide Dynamics in Class I MHC Peptide Binding Grooves

(2009) Francis K. Insaidoo et al.   BIOCHEMISTRY

Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins

(2009) Ivet Bahar et al.   CHEMICAL REVIEWS

Antigen processing and presentation: TAPping into ABC transporters

(2009) Erik Procko et al.   CURRENT OPINION IN IMMUNOLOGY

Hidden talents of natural killers: NK cells in innate and adaptive immunity

(2009) Megan A. Cooper et al.   EMBO REPORTS

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

(2009) Gang Dong et al.   IMMUNITY

Structural immunology and crystallography help immunologists see the immune system in action: How T and NK cells touch their ligands

(2009) Yong Chen et al.   IUBMB LIFE

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

(2009) E. Landais et al.   JOURNAL OF IMMUNOLOGY

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP

(2009) G. Oancea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: A molecular dynamics simulation study

(2008) Rakina Yaneva et al.   BIOPOLYMERS

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Thermodynamics of T‐cell receptor–peptide/MHC interactions: progress and opportunities

(2008) Kathryn M. Armstrong et al.   JOURNAL OF MOLECULAR RECOGNITION

Differential tapasin dependence of MHC class I molecules correlates with conformational changes upon peptide dissociation: A molecular dynamics simulation study

(2008) Florian Sieker et al.   MOLECULAR IMMUNOLOGY

Model for the Peptide-Free Conformation of Class II MHC Proteins

(2008) Corrie A. Painter et al.   PLoS One

The convergent roles of tapasin and HLA-DM in antigen presentation

(2008) Scheherazade Sadegh-Nasseri et al.   TRENDS IN IMMUNOLOGY