Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model

Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)

(2019) Dariusz Włodarek   Nutrients

Exogenous Ketone Bodies as Promising Neuroprotective Agents for Developmental Brain Injury

(2019) Thomas R. Wood et al.   DEVELOPMENTAL NEUROSCIENCE

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

(2018) Steffen E. Storck et al.   BRAIN BEHAVIOR AND IMMUNITY

A nanoformulation for the preferential accumulation in adult neurogenic niches

(2018) Catarina Praça et al.   JOURNAL OF CONTROLLED RELEASE

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice

(2018) David Ma et al.   Scientific Reports

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier

(2018) Tuan Minh Do et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges

(2018) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease

(2018) Miho Ota et al.   NEUROSCIENCE LETTERS

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

(2017) Robert J. Pawlosky et al.   JOURNAL OF NEUROCHEMISTRY

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases

(2017) Ganggang Kong et al.   JOURNAL OF NEUROTRAUMA

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP

(2017) Mariline Gameiro et al.   MOLECULES

On the Metabolism of Exogenous Ketones in Humans

(2017) Brianna J. Stubbs et al.   Frontiers in Physiology

Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders

(2017) Eleni Paleologou et al.   Journal of Clinical Medicine

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Ketogenic diets: from cancer to mitochondrial diseases and beyond

(2016) Ana F. Branco et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

(2016) Kosuke Tanegashima et al.   GENES TO CELLS

Ketones block amyloid entry and improve cognition in an Alzheimer's model

(2016) Jun Xiang Yin et al.   NEUROBIOLOGY OF AGING

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats

(2016) Csilla Ari et al.   Frontiers in Molecular Neuroscience

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

(2015) Pietra Candela et al.   BRAIN RESEARCH

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Hyperketonemia (Acetoacetate) Upregulates NADPH Oxidase 4 and Elevates Oxidative Stress, ICAM-1, and Monocyte Adhesivity in Endothelial Cells

(2015) Preeti Kanikarla-Marie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

(2015) Leif Hertz et al.   JOURNAL OF NEUROCHEMISTRY

Meta-analysis of modifiable risk factors for Alzheimer's disease

(2015) Wei Xu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

(2015) Sophie Gillette-Guyonnet et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Targeting CNS Transporters for Treatment of Neurodegenerative Diseases

(2014) Gabriele Jedlitschky et al.   CURRENT PHARMACEUTICAL DESIGN

Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester

(2014) Sami A. Hashim et al.   JOURNAL OF LIPID RESEARCH

Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy

(2014) Valerie Bomben et al.   NEUROBIOLOGY OF AGING

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of oxysterols on the blood–brain barrier: Implications for Alzheimer’s disease

(2013) Fabien Gosselet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

(2013) Julien Saint-Pol et al.   BRAIN RESEARCH

Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier

(2013) Fabien Gosselet et al.   Current Alzheimer Research

Accelerated Caco-2 cell permeability model for drug discovery

(2013) E. Sevin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Nutrition and the Risk of Alzheimer's Disease

(2013) Nan Hu et al.   Biomed Research International

Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”

(2012) George G. Glenner   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

(2012) Olivia S. Anderson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders

(2012) Carl E. Stafstrom et al.   Frontiers in Pharmacology

Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes

(2011) Elodie Vandenhaute et al.   CURRENT NEUROVASCULAR RESEARCH

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Mild experimental ketosis increases brain uptake of11C-acetoacetate and18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats

(2011) Fabien Pifferi et al.   NUTRITIONAL NEUROSCIENCE

MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction

(2011) Christian Cortés-Campos et al.   PLoS One

Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells

(2011) Dora C. S. Pedroso et al.   PLoS One

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

(2009) Leon M Tai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Issues in Complementary and Alternative Nutrition Treatments

(2009) Gerard E. Mullin   NUTRITION IN CLINICAL PRACTICE

Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-β precursor protein (APP) levels in the aged dog

(2008) Christa M. Studzinski et al.   BRAIN RESEARCH

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

The ketogenic diet: Uses in epilepsy and other neurologic illnesses

(2008) Kristin W. Barañano et al.   Current Treatment Options in Neurology

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice

(2008) Andrea Fuso et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON