Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response

Lasting effects of general anesthetics on the brain in the young and elderly: “mixed picture” of neurotoxicity, neuroprotection and cognitive impairment

(2019) Lingzhi Wu et al.   Journal of Anesthesia

In utero Exposure to Anesthetics Alters Neuronal Migration Pattern in Developing Cerebral Cortex and Causes Postnatal Behavioral Deficits in Rats

(2019) V Gluncic et al.   CEREBRAL CORTEX

Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex

(2019) Hiroshi Kokubun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

(2018) Daniel Hughes et al.   FEBS Journal

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Inhalational Anesthetics Induce Neuronal Protein Aggregation and Affect ER Trafficking

(2018) Matthew Coghlan et al.   Scientific Reports

Dissecting Endoplasmic Reticulum Unfolded Protein Response (UPRER) in Managing Clandestine Modus Operandi of Alzheimer’s Disease

(2018) Safikur Rahman et al.   Frontiers in Aging Neuroscience

Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults

(2018) Y. Zhang et al.   BRITISH JOURNAL OF ANAESTHESIA

Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

(2018) Fu-Yi Shen et al.   Frontiers in Psychiatry

The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

(2018) Kristine Faye R. Pobre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency

(2018) Kathleen A. Trychta et al.   Cell Reports

Decreased Protein Quality Control Promotes the Cognitive Dysfunction Associated With Aging and Environmental Insults

(2018) Hisayo Jin et al.   Frontiers in Neuroscience

Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain

(2018) Bin Liu et al.   BRAIN RESEARCH BULLETIN

Endoplasmic reticulum stress mediates distinct impacts of sevoflurane on different subfields of immature hippocampus

(2017) Gang Zhu et al.   JOURNAL OF NEUROCHEMISTRY

GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway

(2017) Hong-Yan Lu et al.   Molecular Medicine Reports

Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon

(2017) Azeem Alam et al.   NEUROTOXICOLOGY AND TERATOLOGY

Cardioprotection with halogenated gases: how does it occur?

(2017) Jose Luis Guerrero Orriach et al.   Drug Design Development and Therapy

Neurotoxicity versus Neuroprotection of Anesthetics: Young Children on the Ropes?

(2017) Ramón Eizaga Rebollar et al.   PEDIATRIC DRUGS

Entanglement of UPRER in Aging Driven Neurodegenerative Diseases

(2017) Safikur Rahman et al.   Frontiers in Aging Neuroscience

The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration

(2017) Hisayo Jin et al.   Frontiers in Molecular Neuroscience

The genetic background of Parkinson's disease: current progress and future prospects

(2016) K. Kalinderi et al.   ACTA NEUROLOGICA SCANDINAVICA

Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins

(2016) Unni Dokkedal et al.   ANESTHESIOLOGY

Protein aggregation and ER stress

(2016) Navit Ogen-Shtern et al.   BRAIN RESEARCH

Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood

(2016) Lena S. Sun et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anesthesia Exposure and Risk of Dementia and Alzheimer's Disease: A Prospective Study

(2016) Erin J. Aiello Bowles et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

(2016) Andrew J Davidson et al.   LANCET

Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α

(2016) Bin Liu et al.   NEUROTOXICITY RESEARCH

Reelin and Neuropsychiatric Disorders

(2016) Kazuhiro Ishii et al.   Frontiers in Cellular Neuroscience

Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor

(2015) Jessica Raper et al.   ANESTHESIOLOGY

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

(2015) Meiyan Sun et al.   Scientific Reports

Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors

(2014) H. Wang et al.   BRITISH JOURNAL OF ANAESTHESIA

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

Increased risk of dementia in people with previous exposure to general anesthesia: A nationwide population-based case–control study

(2013) Chia-Wen Chen et al.   Alzheimers & Dementia

The Effect of Endoplasmic Reticulum Stress on Neurotoxicity Caused by Inhaled Anesthetics

(2013) Mari Komita et al.   ANESTHESIA AND ANALGESIA

Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells

(2013) Xuli Zhao et al.   ANESTHESIOLOGY

Sevoflurane Anesthesia Does Not Impair Acquisition Learning or Memory in the Morris Water Maze in Young Adult and Aged Rats

(2012) Jennifer K. Callaway et al.   ANESTHESIOLOGY

Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimerʼs disease

(2012) Barbara Eckel et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Calcium Dysregulation in Anesthetic-Mediated Neurotoxicity

(2011) Huafeng Wei   ANESTHESIA AND ANALGESIA

Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice

(2011) George K. Istaphanous et al.   ANESTHESIOLOGY

Cognitive function after sevoflurane- vs propofol-based anaesthesia for on-pump cardiac surgery: a randomized controlled trial

(2011) J. Schoen et al.   BRITISH JOURNAL OF ANAESTHESIA

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery

(2011) R. P. Flick et al.   PEDIATRICS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Genetic Variations in HSPA8 Gene Associated with Coronary Heart Disease Risk in a Chinese Population

(2010) Meian He et al.   PLoS One

Inhalational Anesthetics Induce Cell Damage by Disruption of Intracellular Calcium Homeostasis with Different Potencies

(2009) Hui Yang et al.   ANESTHESIOLOGY

Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

(2009) Greg Stratmann et al.   ANESTHESIOLOGY

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

(2009) Robert T. Wilder et al.   ANESTHESIOLOGY

The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis

(2009) Yiying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH