Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage

(2015) Masato Matsuoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity

(2015) Wenbo Yi et al.   METABOLIC BRAIN DISEASE

Altered Metabolomic Profiles May Be Associated with Sevoflurane-Induced Neurotoxicity in Neonatal Rats

(2015) Bin Liu et al.   NEUROCHEMICAL RESEARCH

Sevoflurane exposure during the neonatal period induces long-term memory impairment but not autism-like behaviors

(2015) Woosuk Chung et al.   PEDIATRIC ANESTHESIA

Endoplasmic reticulum stress pathway mediates isoflurane-induced neuroapoptosis and cognitive impairments in aged rats

(2015) Hong-Wei Ge et al.   PHYSIOLOGY & BEHAVIOR

Anesthetic Preconditioning Inhibits Isoflurane-Mediated Apoptosis in the Developing Rat Brain

(2014) Jun Peng et al.   ANESTHESIA AND ANALGESIA

Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors

(2014) H. Wang et al.   BRITISH JOURNAL OF ANAESTHESIA

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

(2014) Jothi Krishnamoorthy et al.   CELL CYCLE

Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons

(2014) Poonam Goswami et al.   MOLECULAR NEUROBIOLOGY

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells

(2014) Zhiqing Duan et al.   NEUROTOXICOLOGY

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2014) Katherine R. Sadleir et al.   PLoS One

2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro

(2014) Qingxiu Wang et al.   TOXICOLOGY IN VITRO

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells

(2014) Y Teng et al.   Cell Death & Disease

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

The Effect of Endoplasmic Reticulum Stress on Neurotoxicity Caused by Inhaled Anesthetics

(2013) Mari Komita et al.   ANESTHESIA AND ANALGESIA

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

(2013) Xia Shen et al.   ANESTHESIOLOGY

Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis

(2013) József Mandl et al.   MOLECULAR ENDOCRINOLOGY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Sevoflurane Induces Endoplasmic Reticulum Stress Mediated Apoptosis in Hippocampal Neurons of Aging Rats

(2013) Gang Chen et al.   PLoS One

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

(2012) Yiying Zhang et al.   ANNALS OF NEUROLOGY

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

The Role of ER Stress-Induced Apoptosis in Neurodegeneration

(2012) Ioanna C. Stefani et al.   Current Alzheimer Research

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

(2011) Karen M. Doyle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

eIF2  Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation

(2010) Z. Jiang et al.   JOURNAL OF NEUROSCIENCE

Fundamentals of neuronal apoptosis relevant to pediatric anesthesia

(2010) MORGAN BLAYLOCK et al.   PEDIATRIC ANESTHESIA

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

(2010) Do Yeon Lee et al.   PLoS One

The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors

(2009) Huafeng Wei et al.   ANESTHESIOLOGY

Amnestic Concentrations of Sevoflurane Inhibit Synaptic Plasticity of Hippocampal CA1 Neurons through γ-Aminobutyric Acid–mediated Mechanisms

(2009) Junko Ishizeki et al.   ANESTHESIOLOGY

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

(2009) Maiko Satomoto et al.   ANESTHESIOLOGY

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON