Plant cystine-knot peptides: pharmacological perspectives

Variability of Potassium Channel Blockers inMesobuthus eupeusScorpion Venom with Focus on Kv1.1

(2015) Alexey I. Kuzmenkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum

(2015) Roland Hellinger et al.   JOURNAL OF NATURAL PRODUCTS

Allotides: Proline-Rich Cystine Knot α-Amylase Inhibitors from Allamanda cathartica

(2015) Phuong Q. T. Nguyen et al.   JOURNAL OF NATURAL PRODUCTS

64Cu-Labeled Divalent Cystine Knot Peptide for Imaging Carotid Atherosclerotic Plaques

(2015) L. Jiang et al.   JOURNAL OF NUCLEAR MEDICINE

Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

(2015) Franziska Maaß et al.   JOURNAL OF PEPTIDE SCIENCE

A cystine-knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production

(2015) Davide Treggiari et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Plant Antimicrobial Peptides as Potential Anticancer Agents

(2015) Jaquelina Julia Guzmán-Rodríguez et al.   Biomed Research International

Discovery and characterization of pseudocyclic cystine-knot α-amylase inhibitors with high resistance to heat and proteolytic degradation

(2014) Phuong Q. T. Nguyen et al.   FEBS Journal

Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

(2014) Jae H. Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemistry and Biology of Cyclotides: Circular Plant Peptides Outside the Box

(2014) Robert Burman et al.   JOURNAL OF NATURAL PRODUCTS

A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging

(2014) Lei Jiang et al.   MOLECULAR PHARMACEUTICS

99mTc-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Tumor SPECT Imaging

(2014) Xiaohua Zhu et al.   MOLECULAR PHARMACEUTICS

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

(2014) D. C. Tilley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replacing Antibodies: Engineering New Binding Proteins

(2013) Scott Banta et al.   Annual Review of Biomedical Engineering

Cyclotides as grafting frameworks for protein engineering and drug design applications

(2013) Aaron G. Poth et al.   BIOPOLYMERS

Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird SpiderOrnithoctonus hainana

(2013) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel sea anemone peptide that inhibits acid-sensing ion channels

(2013) Armando Alexei Rodríguez et al.   PEPTIDES

Inducible expression of a fusion gene encoding two proteinase inhibitors leads to insect and pathogen resistance in transgenic rice

(2013) Jordi Quilis et al.   PLANT BIOTECHNOLOGY JOURNAL

Novel Inhibitor Cystine Knot Peptides from Momordica charantia

(2013) Wen-Jun He et al.   PLoS One

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

(2013) Bernhard Glotzbach et al.   PLoS One

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

(2013) J. Koehbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma

(2013) Sarah J. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclotides, a Novel Ultrastable Polypeptide Scaffold for Drug Discovery

(2012) Andrew Gould et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

Cyclotides Associate with Leaf Vasculature and Are the Products of a Novel Precursor inPetunia(Solanaceae)

(2012) Aaron G. Poth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

I111n-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis

(2012) Lei Jiang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A new family of cystine knot peptides from the seeds of Momordica cochinchinensis

(2012) Lai Yue Chan et al.   PEPTIDES

Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

(2012) E. Murphy et al.   PLANT CELL

Host-Defense Activities of Cyclotides

(2012) David J. Craik   Toxins

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer

(2011) R. H. Kimura et al.   CLINICAL CANCER RESEARCH

Bioactive cystine knot proteins

(2011) Norelle L Daly et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines

(2011) Shalini Iyer et al.   FEBS Journal

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways

(2011) Janette Contreras et al.   JOURNAL OF CONTROLLED RELEASE

Cysteine-Rich Peptides (CRPs) mediate diverse aspects of cell-cell communication in plant reproduction and development

(2011) E. Marshall et al.   JOURNAL OF EXPERIMENTAL BOTANY

Discovery of an unusual biosynthetic origin for circular proteins in legumes

(2011) A. G. Poth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis and classification of circular proteins in CyBase

(2010) Quentin Kaas et al.   BIOPOLYMERS

Anti-angiogenic effects of two cystine-knot miniproteins from tomato fruit

(2010) C Cavallini et al.   BRITISH JOURNAL OF PHARMACOLOGY

PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide

(2010) C. H. Nielsen et al.   CANCER RESEARCH

Interaction between amphiphilic peptides and phospholipid membranes

(2010) Adam A. Strömstedt et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

(2010) Adam P. Silverman et al.   JOURNAL OF MOLECULAR RECOGNITION

Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides

(2010) J. K. Willmann et al.   JOURNAL OF NUCLEAR MEDICINE

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

(2010) Jun Tang et al.   PEPTIDES

Discovery, structure and biological activities of cyclotides☆

(2009) Norelle L. Daly et al.   ADVANCED DRUG DELIVERY REVIEWS

Cyclotides as templates in drug design

(2009) Sónia Troeira Henriques et al.   DRUG DISCOVERY TODAY

Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

(2009) Christian P. Sommerhoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineered cystine knot peptides that bind αvβ3, αvβ5, and α5β1 integrins with low-nanomolar affinity

(2009) Richard H. Kimura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms

(2008) Michelle L. Colgrave et al.   ACTA TROPICA

The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity

(2008) Michelle L. Colgrave et al.   CHEMBIOCHEM

Cyclic Peptides fromOldenlandia affinisDC. Molecular and Biological Properties

(2008) Lorents Gran et al.   CHEMISTRY & BIODIVERSITY

Ziconotide: an update and review

(2008) Jason A Williams et al.   EXPERT OPINION ON PHARMACOTHERAPY

Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice PestPomacea canaliculata(Golden Apple Snail)

(2008) Manuel Rey R. Plan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

(2008) Sunithi Gunasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distribution and Evolution of Circular Miniproteins in Flowering Plants

(2008) C. W. Gruber et al.   PLANT CELL