Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

Optimization of the cyclotide framework to improve cell penetration properties

(2015) Yen Hua Huang et al.   Frontiers in Pharmacology

Shiga-Like Toxin B Subunit of Escherichia coli as Scaffold for High-Avidity Display of Anti-immunocomplex Peptides

(2014) Gabriel Lassabe et al.   ANALYTICAL CHEMISTRY

Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1

(2014) Charlotte D’Souza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Disulfide-rich macrocyclic peptides as templates in drug design

(2014) Susan E. Northfield et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design of a Cyclotide Antagonist of Neuropilin-1 and -2 That Potently Inhibits Endothelial Cell Migration

(2013) Jennifer A. Getz et al.   ACS Chemical Biology

Cyclotides as grafting frameworks for protein engineering and drug design applications

(2013) Aaron G. Poth et al.   BIOPOLYMERS

Polishing the craft of genetic diversity creation in directed evolution

(2013) Kang Lan Tee et al.   BIOTECHNOLOGY ADVANCES

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

(2013) Yanbin Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering Agatoxin, a Cystine-Knot Peptide from Spider Venom, as a Molecular Probe for In Vivo Tumor Imaging

(2013) Sarah J. Moore et al.   PLoS One

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

(2013) Bernhard Glotzbach et al.   PLoS One

Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma

(2013) Sarah J. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor-Targeting Miniproteins

(2012) Frederic Zoller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Macrocyclization of Peptides Fused to Antibody Fc Fragments

(2012) Alessandro Angelini et al.   BIOCONJUGATE CHEMISTRY

Oxidative Folding of Peptides with Cystine-Knot Architectures: Kinetic Studies and Optimization of Folding Conditions

(2012) Michael Reinwarth et al.   CHEMBIOCHEM

Natural and Engineered Cystine Knot Miniproteins for Diagnostic and Therapeutic Applications

(2012) Harald Kolmar   CURRENT PHARMACEUTICAL DESIGN

Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

(2012) Teshome L. Aboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

(2012) Thomas Hofmeyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Peptibodies: A flexible alternative format to antibodies

(2012) Grant Shimamoto et al.   mAbs

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

(2012) Michael Reinwarth et al.   MOLECULES

PET Imaging of Integrin Positive Tumors Using 18F Labeled Knottin Peptides

(2012) Shuanglong Liu et al.   Theranostics

Protease-Resistant Peptide Ligands from a Knottin Scaffold Library

(2011) Jennifer A. Getz et al.   ACS Chemical Biology

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

(2011) Carlee E. Ashley et al.   ACS Nano

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments

(2011) Christoph Rademacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ipilimumab

(2011) Vernon K. Sondak et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein

(2011) Richard H. Kimura et al.   PLoS One

Disulfide bonds in ER protein folding and homeostasis

(2010) Matthias J Feige et al.   CURRENT OPINION IN CELL BIOLOGY

Random Mutagenesis Methods for In Vitro Directed Enzyme Evolution

(2010) Nikolaos Labrou   CURRENT PROTEIN & PEPTIDE SCIENCE

An improved yeast transformation method for the generation of very large human antibody libraries

(2010) Lorenzo Benatuil et al.   PROTEIN ENGINEERING DESIGN & SELECTION

RGD Dendron Bodies; Synthetic Avidity Agents with Defined and Potentially Interchangeable Effector Sites That Can Substitute for Antibodies

(2009) Daniel Q. McNerny et al.   BIOCONJUGATE CHEMISTRY

Fc-Based Cytokines

(2009) Jalal A Jazayeri et al.   BIODRUGS

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI-I

(2009) Jeffrey Austin et al.   CHEMBIOCHEM

Multimerization of Peptide Mimotopes for Blocking of Factor VIII Neutralizing Antibodies

(2009) Christoph Kessel et al.   ChemMedChem

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

(2009) Christian P. Sommerhoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

(2009) Jennifer L. Lahti et al.   PLoS Computational Biology

A novel solid phase technology for high-throughput gene synthesis

(2008) Jan Van den Brulle et al.   BIOTECHNIQUES

Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

(2008) Harald Kolmar   FEBS Journal

Engineered Cystine-Knot Peptides that Bind αvβ3 Integrin with Antibody-Like Affinities

(2008) Adam P. Silverman et al.   JOURNAL OF MOLECULAR BIOLOGY

One-Pot, Mix-and-Read Peptide-MHC Tetramers

(2008) Christian Leisner et al.   PLoS One

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY