Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

Structural characterization ofSpinacia oleraceatrypsin inhibitor III (SOTI-III)

(2012) Bernhard Glotzbach et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Braces for the Peptide Backbone: Insights into Structure-Activity Relationships of Protease Inhibitor Mimics with Locked Amide Conformations

(2012) Marco Tischler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Folding of Peptides with Cystine-Knot Architectures: Kinetic Studies and Optimization of Folding Conditions

(2012) Michael Reinwarth et al.   CHEMBIOCHEM

I111n-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis

(2012) Lei Jiang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

(2012) Michael Reinwarth et al.   MOLECULES

Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH

(2012) Olga Avrutina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Imaging a functional tumorigenic biomarker in the transformed epithelium

(2012) A. M. LeBeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Synthesis of Potent, Selective Inhibitors of Matriptase

(2012) Éloïc Colombo et al.   ACS Medicinal Chemistry Letters

Protease-Resistant Peptide Ligands from a Knottin Scaffold Library

(2011) Jennifer A. Getz et al.   ACS Chemical Biology

Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase

(2011) Takahiro Domoto et al.   CANCER SCIENCE

A Pseudo MS3 Approach for Identification of Disulfide-Bonded Proteins: Uncommon Product Ions and Database Search

(2011) Jianzhong Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1

(2011) Cai Yuan et al.   BMC STRUCTURAL BIOLOGY

Backbone Dynamics of Cyclotide MCoTI-I Free and Complexed with Trypsin

(2010) Shadakshara S. Puttamadappa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural and mechanistic insight into how antibodies inhibit serine proteases

(2010) Rajkumar Ganesan et al.   BIOCHEMICAL JOURNAL

Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

(2010) Adam P. Silverman et al.   JOURNAL OF MOLECULAR RECOGNITION

Evaluation of a 64Cu-Labeled Cystine-Knot Peptide Based on Agouti-Related Protein for PET of Tumors Expressing  v 3 Integrin

(2010) L. Jiang et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization and 2D NMR study of the stable [9-21, 15-27] 2 disulfide intermediate in the folding of the 3 disulfide trypsin inhibitor EETI II

(2010) D. Le-Nguyen et al.   PROTEIN SCIENCE

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Matriptase: a culprit in cancer?

(2009) Karin List   Future Oncology

Matriptase Activation, an Early Cellular Response to Acidosis

(2009) I-Chu Tseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

(2009) Conan K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

(2009) Christian P. Sommerhoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Sunflower Trypsin Inhibitor 1 Derivatives as Molecular Scaffolds for the Development of Novel Peptidic Radiopharmaceuticals

(2009) Regine García Boy et al.   MOLECULAR IMAGING AND BIOLOGY

Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

(2009) Jennifer L. Lahti et al.   PLoS Computational Biology

A novel solid phase technology for high-throughput gene synthesis

(2008) Jan Van den Brulle et al.   BIOTECHNIQUES

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

(2008) François Stricher et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineered Cystine-Knot Peptides that Bind αvβ3 Integrin with Antibody-Like Affinities

(2008) Adam P. Silverman et al.   JOURNAL OF MOLECULAR BIOLOGY

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY

Head-to-Tail Cyclized Cystine-Knot Peptides by a Combined Recombinant and Chemical Route of Synthesis

(2007) Olga Avrutina et al.   CHEMBIOCHEM