The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases

Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

(2019) Li Zhang et al.   Oxidative Medicine and Cellular Longevity

AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model

(2019) Xuyang Wang et al.   LIFE SCIENCES

AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice

(2018) Jinyu Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ALK is required for NLRP3 inflammasome activation in macrophages

(2018) Bibo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis

(2018) Sherif Rashad et al.   BRAIN RESEARCH

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Caspases-1 and caspase-11 mediate pyroptosis, inflammation, and control of Brucella joint infection

(2018) Carolyn A. Lacey et al.   INFECTION AND IMMUNITY

Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome

(2018) S. Ran et al.   INTERNATIONAL ENDODONTIC JOURNAL

Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations

(2018) Aigli G. Vakrakou et al.   JOURNAL OF AUTOIMMUNITY

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

(2018) Vitaliya Sagulenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classical swine fever virus induces pyroptosis in the peripheral lymphoid organs of infected pigs

(2018) Jin Yuan et al.   VIRUS RESEARCH

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

(2018) Beiyun C. Liu et al.   Cell Reports

Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

(2018) Yaping Wang et al.   PLoS Pathogens

Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection

(2018) Danielle de Oliveira Nascimento et al.   Frontiers in Immunology

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

(2018) Qingling Guo et al.   Frontiers in Immunology

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus

(2018) Zhen-Zhen Ma et al.   Journal of Inflammation-London

AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice

(2018) Miriam Maria Silva Costa Franco et al.   MICROBES AND INFECTION

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

(2018) Xuyao Zhang et al.   Nanoscale

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida

(2018) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis

(2018) Xiaoshan Wu et al.   LABORATORY INVESTIGATION

AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage

(2018) Xiao Lin et al.   Biomed Research International

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

(2017) Tiantian Tang et al.   Nature Communications

Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis

(2017) Huan Liao et al.   Biomed Research International

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

(2017) Beibei Luo et al.   Frontiers in Physiology

AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication

(2017) Thinesshwary Yogarajah et al.   Scientific Reports

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

(2016) Leticia Corrales et al.   JOURNAL OF IMMUNOLOGY

Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2

(2016) J-C Ryu et al.   Mucosal Immunology

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

(2016) Dan Zhao et al.   Oncotarget

Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells

(2016) Karsten Eichholz et al.   PLoS Pathogens

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

(2013) Rebeccah J Mathews et al.   ANNALS OF THE RHEUMATIC DISEASES

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY