In the Wnt-er of life: Wnt signalling in melanoma and ageing

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

(2016) Amanpreet Kaur et al.   NATURE

Dermal fibroblasts induce cell cycle arrest and block epithelial-mesenchymal transition to inhibit the early stage melanoma development

(2016) Linli Zhou et al.   Cancer Medicine

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

(2016) Daniel M. Waldera-Lupa et al.   Aging-US

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

(2015) Faiza Kalfalah et al.   Aging-US

Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging

(2015) Jenny S. Breitenbach et al.   Aging-US

The melanocyte lineage in development and disease

(2015) R. L. Mort et al.   DEVELOPMENT

Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

(2015) Jiri Vachtenheim et al.   EXPERIMENTAL DERMATOLOGY

Age-associated skin changes in innate immunity markers reflect a complex interaction between aging mechanisms in the sebaceous gland

(2015) Rana M. Elewa et al.   JOURNAL OF DERMATOLOGY

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

(2015) Daniel M. Waldera Lupa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

(2015) Alejandro Conde-Perez et al.   Nature Communications

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

(2015) A. Holtzhausen et al.   Cancer Immunology Research

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

(2014) George C. Prendergast et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

(2014) Jamie N. Anastas et al.   JOURNAL OF CLINICAL INVESTIGATION

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

(2014) Marie R. Webster et al.   Pigment Cell & Melanoma Research

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

(2014) Barbara Heidenreich et al.   Nature Communications

Cancer, Aging and Immune Reconstitution

(2013) Stefania Zanussi et al.   Anti-Cancer Agents in Medicinal Chemistry

Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach

(2013) E. Kim et al.   CANCER RESEARCH

Tumor-Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis

(2013) V. Luga et al.   CANCER RESEARCH

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

Klotho Acts as a Tumor Suppressor in Cancers

(2013) Biao Xie et al.   PATHOLOGY & ONCOLOGY RESEARCH

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

(2013) M. P. O'Connell et al.   Cancer Discovery

Genome maintenance and transcription integrity in aging and disease

(2013) Stefanie Wolters et al.   Frontiers in Genetics

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness

(2012) Giuseppina Comito et al.   CANCER LETTERS

Phosphorylation of BRN2 Modulates Its Interaction with the Pax3 Promoter To Control Melanocyte Migration and Proliferation

(2012) I. Berlin et al.   MOLECULAR AND CELLULAR BIOLOGY

Beta-catenin inhibits melanocyte migration but induces melanoma metastasis

(2012) S J Gallagher et al.   ONCOGENE

Identification of Biomarkers of Human Skin Ageing in Both Genders. Wnt Signalling - A Label of Skin Ageing?

(2012) Evgenia Makrantonaki et al.   PLoS One

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Malignant Melanoma in the Elderly: Different Regional Disease and Poorer Prognosis

(2012) James B. Macdonald et al.   Journal of Cancer

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Serum soluble ?-Klotho in hemodialysis patients

(2011) Keitaro Yokoyama et al.   CLINICAL NEPHROLOGY

Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

(2011) H Shao et al.   ONCOGENE

In melanoma, beta-catenin is a suppressor of invasion

(2011) I Arozarena et al.   ONCOGENE

A picture of Mitf in melanoma immortality

(2011) C R Goding   ONCOGENE

Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear

(2010) Masaya Takumida et al.   ACTA OTO-LARYNGOLOGICA

DNA macroarray study of skin aging-related genes expression modulation by antioxidant plant extracts on a replicative senescence model of human dermal fibroblasts

(2010) Stéphanie Dudonné et al.   PHYTOTHERAPY RESEARCH

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility

(2010) Tura C. Camilli et al.   Pigment Cell & Melanoma Research

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells

(2009) Michael P. O'Connell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt

(2009) Michael P. O’Connell et al.   Pigment Cell & Melanoma Research

Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

(2008) S. K. Dissanayake et al.   CANCER RESEARCH

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

(2008) J. Goodall et al.   CANCER RESEARCH

MiTF Regulates Cellular Response to Reactive Oxygen Species through Transcriptional Regulation of APE-1/Ref-1

(2008) Feng Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

(2008) Claudia Wellbrock et al.   PLoS One