WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
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Title
WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
Authors
Keywords
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Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 124, Issue 7, Pages 2877-2890
Publisher
American Society for Clinical Investigation
Online
2014-05-27
DOI
10.1172/jci70156
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Note: Only part of the references are listed.- Frizzled-7 as a Potential Therapeutic Target in Colorectal Cancer
- (2015) Koji Ueno et al. NEOPLASIA
- Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma
- (2015) William D. Tap et al. NEOPLASIA
- WNT5A-NFAT Signaling Mediates Resistance to Apoptosis in Pancreatic Cancer
- (2015) Heidi Griesmann et al. NEOPLASIA
- Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
- (2013) M. P. O'Connell et al. Cancer Discovery
- The Role of the PI3K-AKT Pathway in Melanoma
- (2012) Michael A. Davies CANCER JOURNAL
- Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
- (2012) Hui Zhang et al. CANCER LETTERS
- BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma
- (2012) Y Shao et al. CELL DEATH AND DIFFERENTIATION
- WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis
- (2012) Pei-Tzu Yang et al. EMBO Molecular Medicine
- Reactivation of Mitogen-activated Protein Kinase (MAPK) Pathway by FGF Receptor 3 (FGFR3)/Ras Mediates Resistance to Vemurafenib in Human B-RAF V600E Mutant Melanoma
- (2012) Vipin Yadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With MetastaticBRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor
- (2012) Kevin B. Kim et al. JOURNAL OF CLINICAL ONCOLOGY
- Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition
- (2012) Kavitha Gowrishankar et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- (2012) Ravid Straussman et al. NATURE
- Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
- (2012) Timothy R. Wilson et al. NATURE
- MDM4 is a key therapeutic target in cutaneous melanoma
- (2012) Agnieszka Gembarska et al. NATURE MEDICINE
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth
- (2012) Suping Zhang et al. PLoS One
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt5a: its signalling, functions and implication in diseases
- (2011) A. Kikuchi et al. Acta Physiologica
- Dual inhibition of V600EBRAF and the PI3K/AKT/mTOR pathway cooperates to induce apoptosis in melanoma cells through a MEK-independent mechanism
- (2011) Irene Sánchez-Hernández et al. CANCER LETTERS
- Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
- (2011) F. Su et al. CANCER RESEARCH
- Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis
- (2011) A. Gentile et al. CANCER RESEARCH
- PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
- (2011) K. H. T. Paraiso et al. CANCER RESEARCH
- Frizzled7 as an emerging target for cancer therapy
- (2011) Taj D. King et al. CELLULAR SIGNALLING
- Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling
- (2011) Jason D. Berndt et al. JOURNAL OF CELL BIOLOGY
- Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
- (2011) Nikhil Wagle et al. JOURNAL OF CLINICAL ONCOLOGY
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
- (2011) Julia von Maltzahn et al. NATURE CELL BIOLOGY
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration and is associated with breast cancer progression
- (2011) J N Anastas et al. ONCOGENE
- FZD7 has a critical role in cell proliferation in triple negative breast cancer
- (2011) L Yang et al. ONCOGENE
- Role and therapeutic potential of PI3K-mTOR signaling in de novo resistance to BRAF inhibition
- (2011) W. Deng et al. Pigment Cell & Melanoma Research
- A Switch from Canonical to Noncanonical Wnt Signaling Mediates Drug Resistance in Colon Cancer Cells
- (2011) Michael Bordonaro et al. PLoS One
- Reversing Melanoma Cross-Resistance to BRAF and MEK Inhibitors by Co-Targeting the AKT/mTOR Pathway
- (2011) Mohammad Atefi et al. PLoS One
- WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma
- (2010) Jisheng Li et al. CANCER BIOLOGY & THERAPY
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells
- (2010) Y. N. V. Gopal et al. CANCER RESEARCH
- Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells
- (2010) Y. Shao et al. CANCER RESEARCH
- Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?
- (2010) József Tímár et al. CLINICAL & EXPERIMENTAL METASTASIS
- MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720
- (2010) C. C. Jiang et al. CLINICAL CANCER RESEARCH
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
- (2010) E. W. Joseph et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
- (2009) K Ueno et al. BRITISH JOURNAL OF CANCER
- Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
- (2009) N. Baryawno et al. CANCER RESEARCH
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- An olive branch to two theories
- (2009) Leonie Welberg NATURE REVIEWS NEUROSCIENCE
- The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
- (2009) M P O’Connell et al. ONCOGENE
- Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
- (2009) A. J. Chien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma
- (2008) W. M. Lin et al. CANCER RESEARCH
- WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/ -Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer
- (2008) J. Ying et al. CLINICAL CANCER RESEARCH
- WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome
- (2008) P. D. Da Forno et al. CLINICAL CANCER RESEARCH
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- (2008) J. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt5a Control of Cell Polarity and Directional Movement by Polarized Redistribution of Adhesion Receptors
- (2008) E. S. Witze et al. SCIENCE
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