Regulation of barrier immunity and homeostasis by integrin‐mediated transforming growth factor β activation

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

(2019) Toshiro Hirai et al.   IMMUNITY

Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis

(2019) Yi Yang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

(2019) Nicola Steel et al.   PLoS Pathogens

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

Langerhans Cells: Sensing the Environment in Health and Disease

(2018) Julie Deckers et al.   Frontiers in Immunology

TGF-β receptors: In and beyond TGF-β signaling

(2018) Alexandra Vander Ark et al.   CELLULAR SIGNALLING

Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation

(2018) Aoife Kelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection

(2017) L Denney et al.   Mucosal Immunology

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

(2017) Julie Stockis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing

(2016) Elizabeth K. Duperret et al.   CELL CYCLE

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis

(2016) Katarzyna M. Luda et al.   IMMUNITY

β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage

(2016) Mathilde Boucard-Jourdin et al.   JOURNAL OF IMMUNOLOGY

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

(2016) T M Fenton et al.   Mucosal Immunology

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

(2016) Victoria A. Meliopoulos et al.   PLoS Pathogens

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

(2015) Darren Ruane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β–Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease

(2015) Mitsuo Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

(2015) L M Wakim et al.   Mucosal Immunology

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge

(2014) S. A. Mathie et al.   ALLERGY

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells

(2014) W. Duan et al.   JOURNAL OF IMMUNOLOGY

Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma

(2014) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients

(2013) Aito Ueno et al.   INFLAMMATORY BOWEL DISEASES

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

(2013) John J. Worthington et al.   PLoS Pathogens

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

(2012) Marilyn M. Giacomini et al.   EXPERIMENTAL CELL RESEARCH

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

Pirfenidone

(2011) Natalie J. Carter   DRUGS

Alveolar macrophages modulate allergic inflammation in a murine model of asthma

(2011) Bo-Ram Bang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells

(2011) Helena Païdassi et al.   GASTROENTEROLOGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Inducible CD4+LAP+Foxp3- Regulatory T Cells Suppress Allergic Inflammation

(2011) W. Duan et al.   JOURNAL OF IMMUNOLOGY

Integrin  v 5-Mediated TGF-  Activation by Airway Smooth Muscle Cells in Asthma

(2011) A. L. Tatler et al.   JOURNAL OF IMMUNOLOGY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice

(2010) Andrew C. Melton et al.   JOURNAL OF CLINICAL INVESTIGATION

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

(2010) Mridu Acharya et al.   JOURNAL OF CLINICAL INVESTIGATION

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

(2008) Maria A. Curotto de Lafaille et al.   IMMUNITY

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE