Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

(2017) Florian Wiede et al.   JOURNAL OF AUTOIMMUNITY

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

(2017) Florian Wiede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

(2016) Benjamin Joachim Schmiedel et al.   Nature Communications

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

(2015) Gareth W. Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

(2015) Evita Bothur et al.   Nature Communications

Protein Tyrosine Phosphatase Nonreceptor Type 2: An Important Regulator of lnterleukin-6 Production in Rheumatoid Arthritis Synovial Fibroblasts

(2015) Borbala Aradi et al.   Arthritis & Rheumatology

PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis

(2014) M R Spalinger et al.   Mucosal Immunology

The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2

(2014) Zuoan Yi et al.   NATURE IMMUNOLOGY

PTPN2 attenuates T-cell lymphopenia-induced proliferation

(2014) Florian Wiede et al.   Nature Communications

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Genetics and epigenetics of rheumatoid arthritis

(2013) Sebastien Viatte et al.   Nature Reviews Rheumatology

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

A role for Th17 cells in the regulation of tertiary lymphoid follicles

(2012) Jane L. Grogan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice

(2011) Karen M. Doody et al.   ARTHRITIS AND RHEUMATISM

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Crohnʼs disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation

(2011) Jordan S. Fridman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

The Ets-1 transcription factor controls the development and function of natural regulatory T cells

(2010) Enguerran Mouly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

(2010) Motomu Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

The AP-1 transcription factor Batf controls TH17 differentiation

(2009) Barbara U. Schraml et al.   NATURE

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY