Advances in the role and mechanism of BAG3 in dilated cardiomyopathy

Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies

(2019) Manish K. Gupta et al.   Cell Death & Disease

Action Potential Prolongation, β-Adrenergic Stimulation, and Angiotensin II as Co-factors in Sarcoplasmic Reticulum Instability

(2019) Carlotta Ronchi et al.   Frontiers in Physiology

Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution

(2019) Jana Kohutova et al.   Frontiers in Endocrinology

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

(2019) Jianling Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic RBM20 -Variants Are Associated With a Severe Disease Expression in Male Patients With Dilated Cardiomyopathy

(2019) Thomas Morris Hey et al.   Circulation-Heart Failure

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations

(2019) Suet Nee Chen et al.   CIRCULATION RESEARCH

Targeted interplay between bacterial pathogens and host autophagy

(2019) Padhmanand Sudhakar et al.   Autophagy

GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion

(2019) Xiaoyan Zhang et al.   Autophagy

Physiological levels of chromogranin A prevent doxorubicin-induced cardiotoxicity without impairing its anticancer activity

(2019) Carmine Rocca et al.   FASEB JOURNAL

Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis

(2019) G Xu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The role of autophagy in the pathogenesis of exposure keratitis

(2019) Guoliang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evidence for the impact of BAG3 on electrophysiological activity of primary culture of neonatal cardiomyocytes

(2019) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cardiac Phenotypes, Genetics, and Risks in Familial Noncompaction Cardiomyopathy

(2019) Jaap I. van Waning et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Interaction of Natural Selection and GC Skew May Drive the Fast Evolution of a Sand Rat Homeobox Gene

(2019) Yichen Dai et al.   MOLECULAR BIOLOGY AND EVOLUTION

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

(2019) Jaecheol Lee et al.   NATURE

FUNDC1-mediated mitophagy in bovine papillomavirus-infected urothelial cells

(2019) Sante Roperto et al.   VETERINARY MICROBIOLOGY

Bovine papillomavirus E5 oncoprotein expression and its association with an interactor network in aggresome-autophagy pathway

(2019) Sante Roperto et al.   VETERINARY MICROBIOLOGY

Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes

(2019) Farzaneh Ghasemi Tahrir et al.   Scientific Reports

Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated with Cardiac Morphogenesis and Heart Failure Development

(2019) Nay Aung et al.   CIRCULATION

Mitophagy mediated by BNIP3 and BNIP3L/NIX in urothelial cells of the urinary bladder of cattle harbouring bovine papillomavirus infection

(2019) Sante Roperto et al.   VETERINARY MICROBIOLOGY

A cardiac α-actin (ACTC1) p. Gly247Asp mutation inhibits SRF-signaling in vitro in neonatal rat cardiomyocytes

(2019) Ashraf Yusuf Rangrez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-term life-threatening arrhythmias

(2018) Job A J Verdonschot et al.   EUROPEAN HEART JOURNAL

HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency

(2018) Solenn M. Guilbert et al.   FASEB JOURNAL

Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy

(2018) Andre E. Minoche et al.   GENETICS IN MEDICINE

Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis

(2018) Valerie D. Myers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

BAG3 Protein Is Involved in Endothelial Cell Response to Phenethyl Isothiocyanate

(2018) Silvia Franceschelli et al.   Oxidative Medicine and Cellular Longevity

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

(2018) Anatoli B. Meriin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-assisted selective autophagy in healthy and papillomavirus-associated neoplastic urothelium of cattle

(2018) Sante Roperto et al.   VETERINARY MICROBIOLOGY

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes

(2018) Joseph Y. Cheung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

P209L Mutation in BAG3 Does Not Cause Cardiomyopathy in Mice

(2018) Xi Fang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Protective Effects of Preconditioning With Dioscin on Myocardial Ischemia/Reperfusion-Induced Ventricular Arrhythmias by Increasing Connexin 43 Expression in Rats

(2018) Jin Cheng et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

(2018) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ushering in the cardiac role of Ubiquilin1

(2018) Xi Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

(2018) Fernando Domínguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

(2018) Rahul S. Samant et al.   NATURE

BAG3 plays a central role in proteostasis in the heart

(2017) Wataru Mizushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

(2017) Xi Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Dilated cardiomyopathy

(2017) Robert G Weintraub et al.   LANCET

Upregulation of BAG3 with apoptotic and autophagic activities in maggot extract‑promoted rat skin wound healing

(2017) Jian‑Li Dong et al.   Molecular Medicine Reports

Increased Apoptosis in the Paraventricular Nucleus Mediated by AT1R/Ras/ERK1/2 Signaling Results in Sympathetic Hyperactivity and Renovascular Hypertension in Rats after Kidney Injury

(2017) Hongguo Zhu et al.   Frontiers in Physiology

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling

(2016) Megan T. Quintana et al.   AMERICAN JOURNAL OF PATHOLOGY

Nitrite Reduces Ischemia-Induced Ventricular Arrhythmias by Attenuating Connexin 43 Dephosphorylation in Rats

(2016) Daisuke Maruyama et al.   ANESTHESIA AND ANALGESIA

Making the connections: Autophagy and post-translational modifications in cardiomyocytes

(2016) Manish K. Gupta et al.   Autophagy

Overexpression of BAG3 Attenuates Hypoxia-Induced Cardiomyocyte Apoptosis by Inducing Autophagy

(2016) Jiankai Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

2′-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression

(2016) Hai-Anh Nguyen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes

(2016) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

(2016) Arthur M. Feldman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome

(2016) Sarah Chua et al.   JOURNAL OF PINEAL RESEARCH

NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation

(2016) Mathieu Nivon et al.   MOLECULAR BIOLOGY OF THE CELL

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Familial Dilated Cardiomyopathy Caused by a Novel Frameshift in the BAG3 Gene

(2016) Rocio Toro et al.   PLoS One

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

(2016) Valeria Crippa et al.   Scientific Reports

Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle

(2015) Yu Kitaoka et al.   Applied Physiology Nutrition and Metabolism

Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis

(2015) J Zhao et al.   CELL DEATH AND DIFFERENTIATION

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

BAG3: a new player in the heart failure paradigm

(2015) Tijana Knezevic et al.   HEART FAILURE REVIEWS

BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome

(2015) Anna Kostera-Pruszczyk et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Mutations inHSPB8causing a new phenotype of distal myopathy and motor neuropathy

(2015) Roula Ghaoui et al.   NEUROLOGY

Pacemaker-induced transient asynchrony suppresses heart failure progression

(2015) Jonathan A. Kirk et al.   Science Translational Medicine

Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation

(2015) Raquel Muñoz-Moreno et al.   Viruses-Basel

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53

(2014) Roberta Cotugno et al.   CANCER LETTERS

Atlas of the clinical genetics of human dilated cardiomyopathy

(2014) Jan Haas et al.   EUROPEAN HEART JOURNAL

Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy

(2014) Arthur M. Feldman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation

(2014) Maria Franaszczyk et al.   Journal of Translational Medicine

BAG3 is upregulated by c-Jun and stabilizes JunD

(2013) Chao Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Divergent Mitochondrial Biogenesis Responses in Human Cardiomyopathy

(2013) Preeti Ahuja et al.   CIRCULATION

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Increased 99mTc-Sestamibi Washout Reflects Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients

(2013) Daisuke Hayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Evaluation of Dilated Cardiomyopathy

(2013) Ana Morales et al.   Current Cardiology Reports

Dilated Cardiomyopathy

(2012) Neal K. Lakdawala et al.   Circulation-Arrhythmia and Electrophysiology

Mitochondria in cardiac hypertrophy and heart failure

(2012) Mariana G. Rosca et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

(2011) Carina Roth et al.   BMC CANCER

All the Little Pieces

(2011) Makhosazane Zungu et al.   CIRCULATION JOURNAL

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

BAG3 in heart disease: Novel clues for cardiomyocyte survival from the Z-disk?

(2011) Siegfried Labeit   HUMAN MUTATION

Dilated cardiomyopathy-associatedBAG3mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

(2011) Takuro Arimura et al.   HUMAN MUTATION

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

(2011) Xingqian Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

A comprehensive glossary of autophagy-related molecules and processes

(2010) Daniel J. Klionsky et al.   Autophagy

Rare Variant Mutations in Pregnancy-Associated or Peripartum Cardiomyopathy

(2010) Ana Morales et al.   CIRCULATION

BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

(2010) Akinori Hishiya et al.   CIRCULATION RESEARCH

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells

(2010) Hua-Qin Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

WT1 protein is a transcriptional activator of the antiapoptotic bag3 gene

(2010) E Cesaro et al.   LEUKEMIA

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

(2010) Zagaa Odgerel et al.   NEUROMUSCULAR DISORDERS

Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression

(2009) Hua-Qin Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation

(2008) Serena Carra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

bag3 gene expression is regulated by heat shock factor 1

(2008) Silvia Franceschelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY