Article
Medicine, General & Internal
Tingting Wang, Jinmin Liu, Chenchen Hu, Xin Wei, Linlin Han, Afang Zhu, Rong Wang, Zhijun Chen, Zhengyuan Xia, Shanglong Yao, Weike Mao
Summary: In this study, it was found that downregulation of PIASy reduced ventricular arrhythmias induced by myocardial ischemia/reperfusion (I/R). PIASy downregulation inhibited SUMOylation of Cx43 and increased PKP2 expression, thereby improving I/R-induced ventricular arrhythmias.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Tingting Zhang, Yanyan Wang, Qin Xia, Zhiyi Tu, Jiajun Sun, Qi Jing, Pei Chen, Xuan Zhao
Summary: Cerebral ischemia/reperfusion (I/R) injury results in increased apoptosis of microglial cells and neurons, with propofol protecting the brain against I/R injury by downregulating Cx43.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ping Zhou, Xiaoli Yang, Dezhong Yang, Xin Jiang, Wei Eric Wang, Rongchuan Yue, Yuqiang Fang
Summary: Ischemia reperfusion-induced ventricular arrhythmias can be regulated by ILK agonists and inhibitors, with ILK activation potentially preventing arrhythmias through Akt activation to inhibit Cx43 remodeling.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yi Han, Chang Xiong, Lin-Zhong Zhang, Yi-Di Wang, Guang Yang, Zheng Guo
Summary: This study found that activation of N/OFQ receptor in acute myocardial ischemia leads to the upregulation of p-RKIP, externalization of beta 1-adrenergic receptor, and downregulation of p-Cx43, which promote ventricular arrhythmia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Hirschhaeuser, Alessio Lissoni, Philipp Maximilian Goerge, Paul D. Lampe, Jacqueline Heger, Klaus-Dieter Schlueter, Luc Leybaert, Rainer Schulz, Kerstin Boengler
Summary: The study shows that alterations of Cx43 phosphorylation affect specific cellular functions and highlights the importance of Cx43 phosphorylation by CK1 for IPC's cardioprotection.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Yi, Hongwei Duan, Kaiyuan Chen, Chunlei Wen, Ying Cao, Hong Gao
Summary: This study suggests that MAP changes can serve as a biomarker for arrhythmias in hypothermic ischemia-reperfusion. Experimental findings in isolated rat hearts indicate that prolonged action potential durations, increased dispersion of repolarization, and abnormal expression and distribution of Cx43 may contribute to the derangement of electrical impulse propagation, leading to arrhythmias.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Review
Physiology
Kerstin Boengler, Luc Leybaert, Marisol Ruiz-Meana, Rainer Schulz
Summary: This review discusses the role of Connexins in cell-cell communication and their presence and function in mitochondria. The emphasis is on Cx43 and its impact on mitochondrial function, as well as its involvement in pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lulin Wu, Tianhui Jiang, Zhiping Fu, Luqi Wang, Hongjie You, Jingyi Xue, Dali Luo
Summary: This study reveals that Cx43 S282 dephosphorylation plays a critical role in regulating cardiomyocyte survival and cardiac electrical homeostasis, and contributes to myocardium injury in ischemia/reperfusion. Spontaneous arrhythmias, cardiomyocyte apoptosis and deaths can be induced by Cx43 S282 dephosphorylation based on the degree of dephosphorylation.
Article
Plant Sciences
Yu Kou, Qidi Sun, Rentao Zhu, Zhijie Lin, Zhuoqun Li, Hairong Xu, Xuan Feng, Yanqing Liu
Summary: The study aimed to find a natural drug monomer that can effectively reverse the polarity of tumor-associated macrophages, inhibit melanoma metastasis, and improve survival time. Dioscin was found to repolarize macrophages from M2 to M1 phenotype and suppress melanoma migration, invasion, and metastasis through activation of Cx43-GJs/IFN-gamma/STAT1 pathway and inhibition of Cx43-GJs/IL-4/JAK2/STAT3 pathway.
Article
Food Science & Technology
Yu Kou, Rentao Zhu, Qidi Sun, Zhuoqun Li, Xuan Feng, Hairong Xu
Summary: This study found that Dioscin can inhibit the proliferation, invasion, and metastasis of gastric cancer by increasing the expression of Connexin 43 (Cx43) and suppressing the phosphorylation of the PI3K/Akt signaling pathway, thus inhibiting epithelial-mesenchymal transition (EMT).
FOOD SCIENCE & NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Ya-Qian Jiang, Xiao-Yan Yang, Dan-Qing Duan, Yi-Yue Zhang, Nian-Sheng Li, Li-Jing Tang, Jun Peng, Xiu-Ju Luo
Summary: In this study, the role of MALT1 in regulating ferroptosis in ischemia/reperfusion-induced myocardial injury was investigated. The results showed that MALT1 plays a critical role in regulating the iron death pathway through its interaction with Nrf2. Therefore, inhibition of MALT1 may be a potential therapeutic strategy for treating myocardial infarction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomoki Yamaguchi, Siamak Salavatian, Yuki Kuwabara, Abigail Hellman, Bradley K. Taylor, Kimberly Howard-Quijano, Aman Mahajan
Summary: This study suggests that local administration of RTX to thoracic DRGs can reduce ventricular arrhythmia in a porcine model of IR by inhibiting spinal afferent hyperactivity in the cardio-spinal sympathetic pathways.
Article
Biochemistry & Molecular Biology
Aleksandra V. Durkina, Barbara Szeiffova Bacova, Olesya G. Bernikova, Mikhail A. Gonotkov, Ksenia A. Sedova, Julie Cuprova, Marina A. Vaykshnorayte, Emiliano R. Diez, Natalia J. Prado, Jan E. Azarov
Summary: Melatonin can cause changes in myocardial electrophysiology and prevent ventricular tachycardia or fibrillation in ischemia and reperfusion. The antiarrhythmic effect of melatonin is mediated by receptor-dependent enhancement of impulse conduction, which is associated with the phosphorylation of the intercellular protein Cx43 and maintenance of the resting membrane potential level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Philippe Chevalier, Adrien Moreau, Francis Bessiere, Sylvain Richard, Mohamed Chahine, Gilles Millat, Elodie Morel, Franck Paganelli, Nathalie Lesavre, Leslie Placide, Francois Montestruc, Benedicte Ankou, Rosa Donate Puertas, Babken Asatryan, Antoine Deliniere
Summary: The presence of GJA1 gene variants increases the risk of ventricular fibrillation (VF) in ST-elevation myocardial infarction (STEMI) patients. Beta-blocker intake, atrial fibrillation, and left ventricular ejection fraction >50% decrease the risk of primary VF (PVF). Three novel GJA1 variants were identified, and in vitro studies showed that these variants cause changes in Cx43 localization and cellular communication.