Editorial Material
Biology
Robert DeLong
Summary: The recent meeting at Cold Spring Harbor Laboratory focused on emerging nucleic acid therapies and the essential academic research that has enabled them. The program covered chemical innovations, preclinical and clinical progress, and provided a glimpse of future breakthroughs.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Jiayu Li, Yanguo Xin, Zhaojia Wang, Jingye Li, Weiping Li, Hongwei Li
Summary: Advancements in longevity research have shed light on the impact of cardiac aging on the heart's structure and function. Macrophages play a crucial role in cardiac tissue and demonstrate varied functions in response to injury. This review aims to summarize the roles and characteristics of different subsets of cardiac macrophages in various conditions.
Review
Pharmacology & Pharmacy
Joshua Hurwitz, Lucy Roxana Haggstrom, Elgene Lim
Summary: Antibody-drug conjugates (ADCs) offer new therapeutic options for cancer patients, with the ability to selectively target cancer cells and spare non-malignant tissues. Numerous ADCs are being developed globally, with 13 currently approved. However, limitations such as narrow therapeutic windows, unique toxicity profiles, resistance development, and biomarker selection challenges exist.
Review
Pharmacology & Pharmacy
Beibei Ni, Meijuan Sun, Jun Zhao, Jiao Wang, Zhanqi Cao
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in adult heart development and cardiac tissue homeostasis and is involved in various cardiac diseases. Understanding the role of this pathway in cardiac diseases is important for their treatment and diagnosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katie Trinh, Sohel M. Julovi, Natasha M. Rogers
Summary: The extracellular matrix and ECM-regulatory proteins play crucial roles in cardiac development, organ remodeling, and injury repair. They possess diverse functionality regulated by multiple structural domains and interactions with extracellular substrates and/or cell surface receptors. Various cell types within the myocardium produce ECM proteins, and their importance in cardiovascular physiology and pathology has been increasingly recognized. Understanding the contribution of ECM to cardiovascular disease provides potential pharmacological targets for cardiac diseases and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Han Li, Jinghui Wei, Xuejia Liu, Ping Zhang, Juntang Lin
Summary: Stem cell-based regenerative therapies, particularly Muse cells, show promise for treating stroke. Muse cells have outstanding regenerative abilities and can compensate for the limitations of other stem cells. This review summarizes the recent progress in understanding the biological properties of Muse cells and discusses their application and challenges in stroke treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Yaopeng Hu, Jiehui Cang, Keizo Hiraishi, Takayuki Fujita, Ryuji Inoue
Summary: The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation channel that plays a crucial role in regulating intracellular Ca2+ homeostasis/dynamics in various cellular functions. It has a significant impact on the electrical activity of cardiomyocytes by depolarizing the membrane, and is associated with the development of cardiac arrhythmias. This review highlights the potential of targeting the TRPM4 channel as a novel therapeutic approach for preventing and treating cardiac arrhythmias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jose Miguel Osorio, Claudio Espinoza-Perez, Constanza Rimassa-Tare, Victor Machuca, Juan Ortega Bustos, Matias Vallejos, Hector Vargas, Guillermo Diaz-Araya
Summary: Cardiac fibroblasts play a central role in the development of cardiac fibrosis and can become senescent, leading to organ dysfunction. Early senescence in cardiac fibroblasts after myocardial infarction seems to be protective, but in non-infarcted models, it can be deleterious. New drugs called senolytics and senostatics have emerged as potential therapeutical strategies for treating aging-related cardiac pathologies, but more research is needed to determine their effectiveness in different pathological contexts and timings of intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Physiology
Jinsheng Lai, Chen Chen
Summary: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid produced by cytochrome P450 (CYP) epoxygenases, with beneficial effects against inflammation, fibrosis, and apoptosis in cardiovascular diseases. Studies have shown that increasing EET levels can protect against cardiovascular diseases such as hypertension, myocardial infarction, and heart failure. Therefore, upregulation of EETs may be a potential therapeutic strategy for cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Instruments & Instrumentation
Andrew L. Lewis, Nicholas McEntee, Justin Holland, Asma Patel
Summary: Achieving efficacious systemic levels of orally administered peptides has been incredibly challenging, but the recent approval of Rybelsus (oral semaglutide) represents a significant breakthrough in this field. Through innovative clinical strategies and research efforts, Novo Nordisk has developed a potentially life-changing medicine for diabetic patients with significant commercial potential.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Alina Gabriela Negru, Anda Pastorcici, Simina Crisan, Gabriel Cismaru, Florina Georgeta Popescu, Constantin Tudor Luca
Summary: The importance of magnesium in maintaining normal heart rhythm is still controversial. Magnesium supplementation has been shown to reduce the recurrence of ventricular arrhythmias and improve ventricular response. It also has beneficial effects on the occurrence of polymorphic ventricular tachycardia and supraventricular tachycardia. However, the use of magnesium in the treatment of atrial fibrillation and after cardiac surgery remains controversial.
Review
Biochemistry & Molecular Biology
Yoshimi Kishimoto, Kazuo Kondo, Yukihiko Momiyama
Summary: Sestrin2, an anti-oxidant protein induced by various stresses, plays a protective role against oxidative damage and may serve as a potential therapeutic target for the treatment of atherosclerosis. High blood sestrin2 levels in patients with atherosclerotic diseases may reflect a compensatory response to increased oxidative stress, aiding in the protection against disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jianmin Chen, Lucy V. Norling, Dianne Cooper
Summary: Patients with rheumatoid arthritis have an increased risk of cardiovascular disease, with inflammation playing a key role. Current anti-inflammatory therapeutics used for treating RA patients may have an impact on the development of cardiovascular disease while targeting resolution of inflammation could offer an alternative strategy for controlling inflammation-driven comorbidities in RA.
Article
Multidisciplinary Sciences
Xiu-Yi Kwek, Andrew R. Hall, Wei-Wen Lim, Khairunnisa Katwadi, Poh Loong Soong, Elina Grishina, Kun-Han Lin, Gustavo Crespo-Avilan, En Ping Yap, Nur Izzah Ismail, Kroekkiat Chinda, Ying Ying Chung, Heming Wei, Winston Shim, David Montaigne, Andrew Tinker, Sang-Bing Ong, Derek J. Hausenloy
Summary: Mitochondrial dysfunction induced by acute cardiac ischemia-reperfusion may increase susceptibility to arrhythmias. Mfn-DKO mice exhibit increased action potential duration and reduced conduction velocity, with impaired alterations in CV following cardiac ischemia-reperfusion.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
L. Skora, J. J. A. Livermore, K. Roelofs
Summary: This article explores the functional role of cardiac activity in perception and action, highlighting that cardiac deceleration is an adaptive mechanism that attenuates the impact of baroreceptor signals, enhancing attention to external signals and preparing for appropriate action. Conversely, cardiac acceleration reduces the need for external attention, enhancing action tendencies and behavioral readjustment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Christa L. Blenck, Pamela A. Harvey, Jane F. Reckelhoff, Leslie A. Leinwand
CIRCULATION RESEARCH
(2016)
Article
Cell Biology
Emily K. Pugach, Christa L. Blenck, Joseph M. Dragavon, Stephen J. Langer, Leslie A. Leinwand
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Christa L. Trexler, Aaron T. Odell, Mark Y. Jeong, Robin D. Dowell, Leslie A. Leinwand
CIRCULATION-CARDIOVASCULAR GENETICS
(2017)
Article
Gastroenterology & Hepatology
Hong Wang, Ran Jing, Christa Trexler, Yali Li, Huayuan Tang, Zhixiang Pan, Siting Zhu, Beili Zhao, Xi Fang, Jie Liu, Ju Chen, Kunfu Ouyang
JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Qingsong Lin, Lingyun Zhao, Ran Jing, Christa Trexler, Hong Wang, Yali Li, Huayuan Tang, Fang Huang, Fei Zhang, Xi Fang, Jie Liu, Nan Jia, Ju Chen, Kunfu Ouyang
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Biochemistry & Molecular Biology
Feifei Fan, Yaoyun Duan, Feili Yang, Christa Trexler, Hong Wang, Lei Huang, Yali Li, Huayuan Tang, Gang Wang, Xi Fang, Jie Liu, Nan Jia, Ju Chen, Kunfu Ouyang
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Julius Bogomolovas, Wei Feng, Matthew Daniel Yu, Serena Huang, Lunfeng Zhang, Christa Trexler, Yusu Gu, Simone Spinozzi, Ju Chen
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Review
Medicine, Research & Experimental
Xi Fang, Julius Bogomolovas, Christa Trexler, Ju Chen
