Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated with Cardiac Morphogenesis and Heart Failure Development

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

(2018) Fernando Domínguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

Left ventricular systolic dysfunction during septic shock: the role of loading conditions

(2017) Florence Boissier et al.   INTENSIVE CARE MEDICINE

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

(2017) Philipp S. Wild et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotype and Clinical Outcomes of Titin Cardiomyopathy

(2017) Upasana Tayal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HSPB7 is indispensable for heart development by modulating actin filament assembly

(2017) Tongbin Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

“Canonical and non-canonical actions of GRK5 in the heart”

(2016) Christopher J. Traynham et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

(2016) Arthur M. Feldman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Titin-truncating variants affect heart function in disease cohorts and the general population

(2016) Sebastian Schafer et al.   NATURE GENETICS

Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality

(2016) Ruben N Eppinga et al.   NATURE GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BAG3: a new player in the heart failure paradigm

(2015) Tijana Knezevic et al.   HEART FAILURE REVIEWS

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

(2015) Sophie Garnier et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

(2015) Po-Ru Loh et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

(2015) Angharad M. Roberts et al.   Science Translational Medicine

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Overlapping and Opposing Functions of G Protein-coupled Receptor Kinase 2 (GRK2) and GRK5 during Heart Development

(2014) Melanie Philipp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Left Ventricular Dilation and Incident Congestive Heart Failure in Asymptomatic Adults Without Cardiovascular Disease: Multi-Ethnic Study of Atherosclerosis (MESA)

(2014) Joseph Yeboah et al.   JOURNAL OF CARDIAC FAILURE

Tension-induced autophagy

(2013) Anna Ulbricht et al.   Autophagy

Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis

(2013) Gabriel E. Rosenfeld et al.   DEVELOPMENTAL BIOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking

(2013) Martin D. Burkhalter et al.   Cell Reports

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Progression from Concentric Left Ventricular Hypertrophy and Normal Ejection Fraction to Left Ventricular Dysfunction

(2011) Richard V. Milani et al.   AMERICAN JOURNAL OF CARDIOLOGY

Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular Hypertrophy

(2011) Sonia Shah et al.   Circulation-Cardiovascular Genetics

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Identifying novel constrained elements by exploiting biased substitution patterns

(2009) Manuel Garber et al.   BIOINFORMATICS

Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging

(2009) Christoph A. Busjahn et al.   EUROPEAN HEART JOURNAL

Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study

(2008) Giovanni de Simone et al.   EUROPEAN HEART JOURNAL

The Relationship of Left Ventricular Mass and Geometry to Incident Cardiovascular Events

(2008) David A. Bluemke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

(2008) Stephen B Liggett et al.   NATURE MEDICINE