Oxidative stress accelerates synaptic glutamate dyshomeostasis and NMDARs disorder during methylmercury‐induced neuronal apoptosis in rat cerebral cortex

Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells

(2018) Alessandra Antunes dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

Methylmercury induces oxidative stress and subsequent neural hyperactivity leading to cell death through the p38 MAPK-CREB pathway in differentiated SH-SY5Y cells

(2018) Masatake Fujimura et al.   NEUROTOXICOLOGY

Determination of mercury in hair of children

(2018) A. Pino et al.   TOXICOLOGY LETTERS

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

(2018) Shengquan Hu et al.   Frontiers in Pharmacology

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

(2018) Takamitsu Unoki et al.   Frontiers in Genetics

Assessment of neuroprotective effects of Gallic acid against glutamate-induced neurotoxicity in primary rat cortex neuronal culture

(2018) S. Maya et al.   NEUROCHEMISTRY INTERNATIONAL

Vitamin E-Mediated Modulation of Glutamate Receptor Expression in an Oxidative Stress Model of Neural Cells Derived from Embryonic Stem Cell Cultures

(2017) Afifah Abd Jalil et al.   Evidence-based Complementary and Alternative Medicine

Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice

(2017) Masatake Fujimura et al.   TOXICOLOGY LETTERS

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

(2017) Sonia Sifuentes-Franco et al.   Journal of Diabetes Research

The Antioxidant Cofactor Alpha-Lipoic Acid May Control Endogenous Formaldehyde Metabolism in Mammals

(2017) Anastasia V. Shindyapina et al.   Frontiers in Neuroscience

Ameliorative effects of α-lipoic acid on high-fat diet-induced oxidative stress and glucose uptake impairment of T cells

(2016) Jue Cui et al.   FREE RADICAL RESEARCH

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity

(2016) Dirk Luchtman et al.   JOURNAL OF NEUROCHEMISTRY

Methylmercury and brain development: A review of recent literature

(2016) Alessandra Antunes dos Santos et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway

(2016) Shu Feng et al.   MOLECULAR NEUROBIOLOGY

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

(2016) Takamitsu Unoki et al.   Scientific Reports

Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure

(2015) Marta Obara-Michlewska et al.   NEUROCHEMISTRY INTERNATIONAL

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

(2015) Elżbieta Kania et al.   Biomed Research International

The Bcl-2 family: structures, interactions and targets for drug discovery

(2014) Marc Kvansakul et al.   APOPTOSIS

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults

(2014) Bin Xing et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lipoic acid – biological activity and therapeutic potential

(2014) Anna Gorąca et al.   Pharmacological Reports

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury

(2013) M. Fujimura et al.   ARCHIVES OF TOXICOLOGY

FGF-2 induces neuronal death through upregulation of system xc-

(2013) XiaoQian Liu et al.   BRAIN RESEARCH

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

(2013) Abasha Lewis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Long-lasting neurotoxic effects of exposure to methylmercury during development

(2013) S. Ceccatelli et al.   JOURNAL OF INTERNAL MEDICINE

Role of Intracellular Defense Factors against Methylmercury Toxicity

(2012) Gi-Wook Hwang   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity

(2012) Ingrid Morales et al.   GLIA

MK-801 Protects against Intracellular Ca2+ Overloading and Improves N-methyl-d-aspartate Receptor Expression in Cerebral Cortex of Methylmercury-Poisoned Rats

(2012) Bin Xu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The toxicology of mercury and its compounds

(2012) Tore Syversen et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy

(2012) Naoki Ito et al.   NATURE MEDICINE

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation

(2012) Kai Connie Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of xCT expression and system $$ x_{\text{c}}^{ - } $$ function in neuronal cells

(2011) Jan Lewerenz et al.   AMINO ACIDS

Protection from Glutamate-Induced Excitotoxicity by Memantine

(2011) Melinda K. Kutzing et al.   ANNALS OF BIOMEDICAL ENGINEERING

Control of oxidative stress by the Keap1-Nrf2 pathway

(2011) J. D. Stewart et al.   ARCHIVES OF TOXICOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Glutamate NMDA receptor dysregulation in Parkinson’s disease with dyskinesias

(2011) Imtiaz Ahmed et al.   BRAIN

Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury

(2011) Takashi Toyama et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo

(2011) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

DNA microarray analysis of human neuroblastoma SH-SY5Y cells exposed to methylmercury

(2011) Takashi Toyama et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies

(2011) Marcelo Farina et al.   LIFE SCIENCES

Methylmercury and Brain Development: Imprecision and Underestimation of Developmental Neurotoxicity in Humans

(2011) Philippe Grandjean et al.   MOUNT SINAI JOURNAL OF MEDICINE

Oxidative stress in MeHg-induced neurotoxicity

(2011) Marcelo Farina et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury

(2011) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

Methylmercury-induced neurotoxicity and apoptosis

(2010) Sandra Ceccatelli et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons

(2010) Yuki Kambe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1

(2010) Helisoa Razafimanjato et al.   NEUROTOXICOLOGY

NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization

(2010) Yu Luo et al.   PLoS One

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

(2009) Kate Petersen Shay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

L-Glutamate Enhances Methylmercury Toxicity by Synergistically Increasing Oxidative Stress

(2008) Sirirat Amonpatumrat et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes

(2008) Ling Wang et al.   TOXICOLOGICAL SCIENCES

Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain

(2007) James Stringari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY