Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport

(2017) Arunas Kvainickas et al.   JOURNAL OF CELL BIOLOGY

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR

(2017) Boris Simonetti et al.   JOURNAL OF CELL BIOLOGY

Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion

(2017) Latha Kallur Purushothaman et al.   MOLECULAR BIOLOGY OF THE CELL

Rab GTPases: master regulators that establish the secretory and endocytic pathways

(2017) Suzanne R. Pfeffer   MOLECULAR BIOLOGY OF THE CELL

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

(2017) Srirupa Roy et al.   MOLECULAR CELL

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

(2016) Da Jia et al.   Nature Communications

FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus

(2016) Seongju Lee et al.   Nature Communications

Global, quantitative and dynamic mapping of protein subcellular localization

(2016) Daniel N Itzhak et al.   eLife

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

VARP Is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface

(2014) Geoffrey G. Hesketh et al.   DEVELOPMENTAL CELL

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

(2014) C. L. Freeman et al.   JOURNAL OF CELL SCIENCE

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Molecular Insights into Rab7-Mediated Endosomal Recruitment of Core Retromer: Deciphering the Role of Vps26 and Vps35

(2014) Amulya Priya et al.   TRAFFIC

Retromer: A Master Conductor of Endosome Sorting

(2014) C. Burd et al.   Cold Spring Harbor Perspectives in Biology

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Endosomal recruitment of the WASH complex: Active sequences and mutations impairing interaction with the retromer

(2013) Emmanuèle Helfer et al.   BIOLOGY OF THE CELL

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

A mechanism for retromer endosomal coat complex assembly with cargo

(2013) M. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

(2012) Jan R T van Weering et al.   EMBO JOURNAL

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers

(2012) D. Popovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

(2012) Da Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

(2012) Badri N. Vardarajan et al.   NEUROBIOLOGY OF AGING

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

VPS29 Is Not an Active Metallo-Phosphatase but Is a Rigid Scaffold Required for Retromer Interaction with Accessory Proteins

(2011) James D. Swarbrick et al.   PLoS One

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Retromer Sorting

(2008) Scott A. Small   ARCHIVES OF NEUROLOGY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA