Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators

In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites

(2019) Yuli Qian et al.   DRUG METABOLISM AND DISPOSITION

Label-free absolute protein quantification with data-independent acquisition

(2019) Bing He et al.   Journal of Proteomics

Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1

(2019) Eliane Briand et al.   MOLECULES

Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis

(2018) Jihong Lian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Evaluating oseltamivir prescriptions in Centers for Medicare and Medicaid Services medical claims records as an indicator of seasonal influenza in the United States

(2018) F. Scott Dahlgren et al.   Influenza and Other Respiratory Viruses

Prodrugs – Recent approvals and a glimpse of the pipeline

(2017) Jarkko Rautio et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers

(2017) Hao-Jie Zhu et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

US Epidemiology of Cannabis Use and Associated Problems

(2017) Deborah S Hasin   NEUROPSYCHOPHARMACOLOGY

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans

(2017) Jaeseong Oh et al.   PLoS One

Limb proportions show developmental plasticity in response to embryo movement

(2017) A. S. Pollard et al.   Scientific Reports

Carboxylesterases in lipid metabolism: from mouse to human

(2017) Jihong Lian et al.   Protein & Cell

Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms

(2016) Jian Shi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender

(2016) Jian Shi et al.   BIOCHEMICAL PHARMACOLOGY

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

(2016) Mikael Boberg et al.   DRUG METABOLISM AND DISPOSITION

Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis

(2016) Zhigang Zhao et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

CES1P1 variant −816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril

(2016) Hao-Jie Zhu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults

(2016) Xi-Ling Jiang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors

(2016) Karl E. Nelveg-Kristensen et al.   Pharmacogenetics and Genomics

Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full-length protein calibrators (TAQSI)

(2016) Xinwen Wang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

(2015) E. Katriina Tarkiainen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors

(2015) Alex M. Cressman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

(2015) EK Tarkiainen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin

(2015) Laura M. Bozzi et al.   Current Vascular Pharmacology

CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors

(2015) X Wang et al.   PHARMACOGENOMICS JOURNAL

Change in prescription pattern as a potential marker for adverse drug reactions of angiotensin converting enzyme inhibitors

(2015) Seyed Hamidreza Mahmoudpour et al.   International Journal of Clinical Pharmacy

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

(2015) Victoria Arena de Souza et al.   PLoS One

G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharm Res 12, 413–420, 1995—Backstory of BCS

(2014) Vinod P. Shah et al.   AAPS Journal

Effects of Alcohol on Human Carboxylesterase Drug Metabolism

(2014) Robert B. Parker et al.   CLINICAL PHARMACOKINETICS

Physiologically Based Pharmacokinetic Modeling of Impaired Carboxylesterase-1 Activity: Effects on Oseltamivir Disposition

(2014) Zhe-Yi Hu et al.   CLINICAL PHARMACOKINETICS

Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study

(2014) K E Kristensen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The effects of CES1A2 A(−816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease

(2014) Cheng Xie et al.   Pharmacogenetics and Genomics

Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels

(2014) Jiesi Xu et al.   PLoS One

Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

(2013) Guillaume Paré et al.   CIRCULATION

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update

(2013) S A Scott et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CES1A −816C as a Genetic Marker to Predict Greater Platelet Clopidogrel Response in Patients with Percutaneous Coronary Intervention

(2013) Jian-Jun Zou et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit/Hyperactivity Disorder-Associated CES1 Gene

(2013) Katherine A. Johnson et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

(2013) S. Casey Laizure et al.   PHARMACOTHERAPY

Carboxylesterase 1 Gene Duplication and mRNA Expression in Adipose Tissue Are Linked to Obesity and Metabolic Function

(2013) Martin Friedrichsen et al.   PLoS One

Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation

(2012) Da Xiao et al.   BIOCHEMICAL PHARMACOLOGY

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

(2012) E K Tarkiainen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Emerging Role of Human Esterases

(2012) Tatsuki Fukami et al.   Drug Metabolism and Pharmacokinetics

The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans

(2012) Yuki Suzaki et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population

(2012) Yuki Suzaki et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization

(2012) Matthew T. Roe et al.   NEW ENGLAND JOURNAL OF MEDICINE

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response

(2012) Joshua P. Lewis et al.   Pharmacogenetics and Genomics

Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate

(2012) E M Bruxel et al.   PHARMACOGENOMICS JOURNAL

Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice

(2012) William C. Griffin et al.   PSYCHOPHARMACOLOGY

Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography–tandem mass spectrometry: Application to human ethanol interactions

(2011) Hao-Jie Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir

(2011) Deshi Shi et al.   JOURNAL OF INFECTIOUS DISEASES

Transdermal and Oral dl-Methylphenidate–Ethanol Interactions in C57BL/6J Mice: Transesterification to Ethylphenidate and Elevation of d-Methylphenidate Concentrations

(2011) Guinevere H. Bell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction and In Vitro Evaluation of Selected Protease Inhibitor Antiviral Drugs as Inhibitors of Carboxylesterase 1: A Potential Source of Drug-Drug Interactions

(2011) Jenna A. Rhoades et al.   PHARMACEUTICAL RESEARCH

Oral and transdermal dl-methylphenidate–ethanol interactions in C57BL/6J mice: Potentiation of locomotor activity with oral delivery

(2011) Guinevere H. Bell et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

(2010) Kimie Sai et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Nuclear receptor-mediated regulation of carboxylesterase expression and activity

(2010) Jeff L Staudinger et al.   Expert Opinion on Drug Metabolism & Toxicology

Carboxylesterases: dual roles in lipid and pesticide metabolism

(2010) Matthew K. Ross et al.   JOURNAL OF PESTICIDE SCIENCE

Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity

(2010) S Yamada et al.   PHARMACOGENOMICS JOURNAL

The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice

(2010) William C. Griffin III et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions

(2010) Hao-Jie Zhu et al.   TOXICOLOGY

Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril

(2009) Hao-Jie Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

(2009) J. Allen Crow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver

(2009) H.-J. Zhu et al.   DRUG METABOLISM AND DISPOSITION

Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD

(2009) Zsofia Nemoda et al.   NEUROPHARMACOLOGY

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage cholesteryl ester mobilization and atherosclerosis

(2009) Shobha Ghosh et al.   VASCULAR PHARMACOLOGY

Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis

(2008) Hao-Jie Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites

(2008) Mika Yoshimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

(2008) Dongfang Yang et al.   BIOCHEMICAL PHARMACOLOGY

Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants

(2008) H.-J. Zhu et al.   DRUG METABOLISM AND DISPOSITION

Structural Organization and Characterization of the Regulatory Element of the Human Carboxylesterase (CES1A1 and CES1A2) genes

(2008) Masakiyo Hosokawa et al.   Drug Metabolism and Pharmacokinetics

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes

(2008) Tatsuki Fukami et al.   Pharmacogenetics and Genomics

Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: Evidence for an involvement of the glucocorticoid receptor

(2008) Deshi Shi et al.   TOXICOLOGY