Physiologically Based Pharmacokinetic Modeling of Impaired Carboxylesterase-1 Activity: Effects on Oseltamivir Disposition

Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometry

(2014) Zhe-Yi Hu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Physiologically based pharmacokinetic modelling andin vivo[I]/Kiaccurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate

(2013) Yuansheng Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

(2013) Guillaume Paré et al.   CIRCULATION

Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations

(2013) Vicky Hsu et al.   CLINICAL PHARMACOKINETICS

Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

(2013) Md L T Vieira et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

(2013) H J Einolf et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of the Inhibitory Effects of Antihypertensive Drugs on Human Carboxylesterase In Vitro

(2013) Xu Yanjiao et al.   Drug Metabolism and Pharmacokinetics

Neuropsychiatric Adverse Events and Oseltamivir for Prophylaxis

(2013) Mark Jones et al.   DRUG SAFETY

Modulation of Esterified Drug Metabolism by Tanshinones from Salvia miltiorrhiza (“Danshen”)

(2013) M. Jason Hatfield et al.   JOURNAL OF NATURAL PRODUCTS

The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

(2013) S. Casey Laizure et al.   PHARMACOTHERAPY

Safety, Tolerability, and Pharmacokinetics of Intravenous Oseltamivir: Single- and Multiple-Dose Phase I Studies with Healthy Volunteers

(2012) Barbara J. Brennan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

(2012) Lyudmila G. Tsurkan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

(2012) E K Tarkiainen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves

(2012) Li Li et al.   CURRENT DRUG METABOLISM

CYP2C metabolism of oral antidiabetic drugs - impact on pharmacokinetics, drug interactions and pharmacogenetic aspects

(2012) Andreas Holstein et al.   Expert Opinion on Drug Metabolism & Toxicology

Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry: Improved applicability to pharmacokinetic study

(2012) Zhe-Yi Hu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

(2012) Fatma Goksin Bahar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response

(2012) Joshua P. Lewis et al.   Pharmacogenetics and Genomics

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

(2011) Neil Parrott et al.   CLINICAL PHARMACOKINETICS

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolution of a Detailed Physiological Model to Simulate the Gastrointestinal Transit and Absorption Process in Humans, Part II: Extension to Describe Performance of Solid Dosage Forms

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction and In Vitro Evaluation of Selected Protease Inhibitor Antiviral Drugs as Inhibitors of Carboxylesterase 1: A Potential Source of Drug-Drug Interactions

(2011) Jenna A. Rhoades et al.   PHARMACEUTICAL RESEARCH

Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling

(2010) Nathalie Perdaems et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions

(2010) Hao-Jie Zhu et al.   TOXICOLOGY

The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions

(2009) R. B. Parker et al.   DRUG METABOLISM AND DISPOSITION

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

(2009) R. Z. Cer et al.   NUCLEIC ACIDS RESEARCH

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

(2009) Ans Punt et al.   TOXICOLOGICAL SCIENCES

Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis

(2008) Hao-Jie Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers

(2008) Y. Wattanagoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants

(2008) H.-J. Zhu et al.   DRUG METABOLISM AND DISPOSITION