Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM)

(2019) Changjiang Lei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epidemiology of osteoarthritis

(2018) Ernest R. Vina et al.   CURRENT OPINION IN RHEUMATOLOGY

An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis

(2018) Chao Tu et al.   CYTOKINE

Obesity and diabetes-Not only a simple link between two epidemics

(2018) Agata Chobot et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures

(2018) Dongrim Seol et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative

(2018) J. Neumann et al.   OSTEOARTHRITIS AND CARTILAGE

The impact of hip and knee osteoarthritis on the subsequent risk of incident diabetes: a population-based cohort study

(2018) Tetyana Kendzerska et al.   DIABETOLOGIA

The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis

(2018) J.D. Guss et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage Oligomeric Matrix Protein Levels in Type 2 Diabetes Associated with Primary Knee Osteoarthritis Patients

(2018) Ruben Daniel Arellano Perez Vertti et al.   Genetic Testing and Molecular Biomarkers

A Complex Relationship between Visfatin and Resistin and microRNA: An In Vitro Study on Human Chondrocyte Cultures

(2018) Sara Cheleschi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Correlation between Diabetes Mellitus and Knee Osteoarthritis: A Dry-To-Wet Lab Approach

(2018) Navneet Dubey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of high-risk groups for complication after arthroplasty: predictive value of patient’s related risk factors

(2018) Martha Cecilia Castano-Betancourt et al.   Journal of Orthopaedic Surgery and Research

The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis

(2017) Carlos Vaamonde-Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

(2017) Weidong Zhang et al.   PLoS One

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

(2016) Anne-Laurence Tomi et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis and type 2 diabetes mellitus: What are the links?

(2016) Alice Courties et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Bone mineral density and intervertebral disc height in type 2 diabetes

(2016) Rachel Agius et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis

(2016) Mia F. Williams et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis

(2016) Stefano Ballestri et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis

(2016) Z.M. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis

(2016) W. de Munter et al.   OSTEOARTHRITIS AND CARTILAGE

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation

(2016) Z.Y. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Insulin decreases autophagy and leads to cartilage degradation

(2016) M. Ribeiro et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year in review 2015: mechanics

(2016) N.H. Varady et al.   OSTEOARTHRITIS AND CARTILAGE

Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case–control analysis

(2016) N. Frey et al.   OSTEOARTHRITIS AND CARTILAGE

Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis

(2016) K Hashimoto et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Longitudinal Change in Thigh Muscle Strength Prior to and Concurrent With Minimum Clinically Important Worsening or Improvement in Knee Function: Data From the Osteoarthritis Initiative

(2016) Anja Ruhdorfer et al.   Arthritis & Rheumatology

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

(2016) Daisuke Hamada et al.   Arthritis & Rheumatology

Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study

(2016) Carlen Reyes et al.   Arthritis & Rheumatology

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Use of thiazolidinediones and the risk of elective hip or knee replacement: a population based case-control study

(2015) Johannes T.H. Nielen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study

(2015) H.Y. Yang et al.   GENETICS AND MOLECULAR RESEARCH

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

(2015) Magdalena Richter et al.   INTERNATIONAL ORTHOPAEDICS

Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation

(2015) Ying-Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Does lipopolysaccharide-mediated inflammation have a role in OA?

(2015) Zeyu Huang et al.   Nature Reviews Rheumatology

Viscosupplementation for Osteoarthritis of the Knee

(2015) David J. Hunter   NEW ENGLAND JOURNAL OF MEDICINE

Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model

(2015) K.H. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Vastus medialis fat infiltration – a modifiable determinant of knee cartilage loss

(2015) A.J. Teichtahl et al.   OSTEOARTHRITIS AND CARTILAGE

Diabetes is a risk factor for knee osteoarthritis progression

(2015) F. Eymard et al.   OSTEOARTHRITIS AND CARTILAGE

High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis?

(2015) Wouter de Munter et al.   RHEUMATOLOGY

Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population-Based Study

(2015) Karin Magnusson et al.   ARTHRITIS CARE & RESEARCH

Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation

(2014) Yi He et al.   BMC MUSCULOSKELETAL DISORDERS

Down-Regulation of Adiponectin Receptors in Osteoarthritic Chondrocytes

(2014) Qiang Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte

(2014) Qingshan Yang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages

(2014) Ying-Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Association between adiponectin and cartilage degradation in human osteoarthritis

(2014) P.-J. Francin et al.   OSTEOARTHRITIS AND CARTILAGE

Adiponectin Enhances Intercellular Adhesion Molecule-1 Expression and Promotes Monocyte Adhesion in Human Synovial Fibroblasts

(2014) Hsien-Te Chen et al.   PLoS One

Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis

(2014) Marie-Charlotte Laiguillon et al.   ARTHRITIS RESEARCH & THERAPY

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

(2013) Siyoung Yang et al.   ANNALS OF THE RHEUMATIC DISEASES

A Lipidomic Study of Phospholipid Classes and Species in Human Synovial Fluid

(2013) Marta Krystyna Kosinska et al.   ARTHRITIS AND RHEUMATISM

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

Contemporary Risk of Hip Fracture in Type 1 and Type 2 Diabetes: A National Registry Study From Scotland

(2013) Eleanor J Hothersall et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Plasma Adipokine Levels and Their Association with Overall Burden of Painful Joints among Individuals with Hip and Knee Osteoarthritis

(2013) A. V. Perruccio et al.   JOURNAL OF RHEUMATOLOGY

Cam impingement of the hip—a risk factor for hip osteoarthritis

(2013) Rintje Agricola et al.   Nature Reviews Rheumatology

Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK)

(2013) R. Agricola et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced Glycation End Products Induce Peroxisome Proliferator-Activated Receptor γ Down-Regulation-Related Inflammatory Signals in Human Chondrocytes via Toll-Like Receptor-4 and Receptor for Advanced Glycation End Products

(2013) Ying Ju Chen et al.   PLoS One

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

(2013) Wouter de Munter et al.   ARTHRITIS RESEARCH & THERAPY

Time-of-Flight Secondary Ion Mass Spectrometry-Based Molecular Distribution Distinguishing Healthy and Osteoarthritic Human Cartilage

(2012) Berta Cillero-Pastor et al.   ANALYTICAL CHEMISTRY

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation

(2012) Chun-Hao Tsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study

(2012) G. Schett et al.   DIABETES CARE

Increased fasting serum glucose concentration is associated with adverse knee structural changes in adults with no knee symptoms and diabetes

(2012) Miranda L. Davies-Tuck et al.   MATURITAS

Does diabetes hide osteoarthritis pain?

(2012) Paul E. Leaverton et al.   MEDICAL HYPOTHESES

Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK

(2012) W.E. Van Spil et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of mesenchymal stem cell chondrogenesis by glucose through protein kinase C/transforming growth factor signaling

(2012) T.-L. Tsai et al.   OSTEOARTHRITIS AND CARTILAGE

Adiponectin and Leptin Induce VCAM-1 Expression in Human and Murine Chondrocytes

(2012) Javier Conde et al.   PLoS One

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise

(2011) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Nicotinamide Phosphoribosyltransferase Is Essential for Interleukin-1β-mediated Dedifferentiation of Articular Chondrocytes via SIRT1 and Extracellular Signal-regulated Kinase (ERK) Complex Signaling

(2011) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin

(2011) S.C. Rosa et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes

(2011) C.-Y. Huang et al.   RHEUMATOLOGY

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis

(2010) Dongsheng Hao et al.   RHEUMATOLOGY INTERNATIONAL

Persistent High Glucose Concentrations Alter the Regenerative Potential of Mesenchymal Stem Cells

(2010) Christopher Cramer et al.   STEM CELLS AND DEVELOPMENT

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

(2010) Feng-Cheng Liu et al.   ARTHRITIS RESEARCH & THERAPY

High Levels of Tumor Necrosis Factor-α Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing

(2009) Jazia Alblowi et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis

(2009) M Filkova et al.   ANNALS OF THE RHEUMATIC DISEASES

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

(2009) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-InducedPGE2, IL-6, and IL-8 Production

(2009) Katriina Vuolteenaho et al.   MEDIATORS OF INFLAMMATION

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage

(2009) L.A. Collins-Racie et al.   OSTEOARTHRITIS AND CARTILAGE

Increased Prevalence of Metabolic Syndrome in Individuals with Osteoarthritis: An Analysis of NHANES III Data

(2009) Rajitkanok Amy Puenpatom et al.   POSTGRADUATE MEDICINE

Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage

(2009) Susana C Rosa et al.   ARTHRITIS RESEARCH & THERAPY

The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

(2008) F Pessler et al.   ANNALS OF THE RHEUMATIC DISEASES

The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate on blood glucose levels in controlled diabetic patients with symptomatic osteoarthritis of the knee

(2008) George Habib et al.   CLINICAL RHEUMATOLOGY

A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes

(2008) R. Lago et al.   OSTEOARTHRITIS AND CARTILAGE

Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro

(2008) J.H. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

High glucose induces adipogenic differentiation of muscle-derived stem cells

(2008) P. Aguiari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA