NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

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Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

Epigenetics, sirtuins and osteoarthritis

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Switching gears to an arthritis gene expression network by SirT1 cleavage

(2011) Hiroshi Asahara   ARTHRITIS AND RHEUMATISM

Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthrit

(2011) Laura Evans et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis

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Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

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Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

(2011) Shin-ichiro Imai   FEBS LETTERS

Nicotinamide Phosphoribosyltransferase Is Essential for Interleukin-1β-mediated Dedifferentiation of Articular Chondrocytes via SIRT1 and Extracellular Signal-regulated Kinase (ERK) Complex Signaling

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Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner

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What's new in our understanding of the role of adipokines in rheumatic diseases?

(2011) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis

(2011) Yuanhui Duan et al.   RHEUMATOLOGY INTERNATIONAL

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

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Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis

(2009) Young Hee Rho et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

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Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases

(2009) Shin-ichiro Imai   CURRENT PHARMACEUTICAL DESIGN

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

(2009) Rodolfo Gomez et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

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Developments in the scientific understanding of osteoarthritis

(2009) Steven B Abramson et al.   ARTHRITIS RESEARCH & THERAPY

Crucial role of visfatin/pre–B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis

(2008) Marjolaine Gosset et al.   ARTHRITIS AND RHEUMATISM

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

(2008) Nathalie Busso et al.   PLoS One